{"id":"W1967945239","doi":"10.1091/mbc.e08-08-0845","title":"Novel Roles of Hakai in Cell Proliferation and Oncogenesis","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Hakai Institute","keywords":"Biology; Cell growth; Carcinogenesis; Gene knockdown; Ubiquitin ligase; Cell biology; Alternative splicing; RNA-binding protein; Cell; RNA splicing; Molecular biology; RNA; Ubiquitin; Cell culture; Messenger RNA; Cancer; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714932,0.0000832298,0.0001284992,0.00004610093,0.00002248715,0.00000295536,0.0001756721,0.0001254575,0.000001406885],"category_scores_gemma":[0.00003130086,0.00006243693,0.00005912436,0.00007691701,0.00009865157,0.00000138754,0.0000776037,0.00005868495,3.217267e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004519368,"about_ca_system_score_gemma":0.00004264988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003190662,"about_ca_topic_score_gemma":0.000035857,"domain_scores_codex":[0.9993681,0.00007612492,0.0001696216,0.0001781907,0.00005865374,0.000149289],"domain_scores_gemma":[0.9996073,0.000006788431,0.00008075887,0.0002322797,0.00004356939,0.00002932477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005056785,0.00009084013,0.005457697,0.00001627788,0.000005844521,5.174948e-7,0.00002568702,0.00008245951,0.992947,0.00005477239,0.00002044368,0.001247885],"study_design_scores_gemma":[0.0004949202,0.0003134456,0.004197908,0.000008306802,0.000006025099,0.000002833294,0.0000246837,0.0001152353,0.9944909,0.0001290982,0.0001548365,0.00006177417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952334,0.001610896,0.00224276,0.0002300561,0.00001659771,0.0001563794,0.000006992928,0.000001484454,0.0005014426],"genre_scores_gemma":[0.9986248,0.000108354,0.0008386376,0.0001514522,0.00001263513,0.000003507105,0.00001302481,0.000005578286,0.0002420202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0033914,"threshold_uncertainty_score":0.2546104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006673080325885899,"score_gpt":0.2502118844869039,"score_spread":0.243538804161018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}