{"id":"W1967949522","doi":"10.4021/gr2008.10.1240","title":"Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma","year":2008,"lang":"en","type":"article","venue":"Gastroenterology Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Southeast University; National Natural Science Foundation of China","keywords":"DNMT3B; DNMT1; DNA methyltransferase; Epigenetics; Methyltransferase; DNA methylation; CpG site; Hepatocellular carcinoma; Epigenetic therapy; Molecular biology; Gene; Cancer research; Methylation; Biology; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169937,0.0002800633,0.0002816479,0.0002772459,0.000125336,0.0001558578,0.0001738133,0.0002513217,0.002755084],"category_scores_gemma":[0.00009429693,0.00007590085,0.0003360176,0.0002108933,0.0001363283,0.0001395474,0.0001517538,0.0005079403,0.0005553029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000359539,"about_ca_system_score_gemma":0.0002643815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007218761,"about_ca_topic_score_gemma":0.001731433,"domain_scores_codex":[0.9999487,0.000008706327,0.000004322071,0.000009059262,0.00001671879,0.0000125004],"domain_scores_gemma":[0.9999596,0.000006937817,0.00001223207,0.000004779346,0.000007704295,0.00000864203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007663313,0.0002264511,0.002696874,0.001262815,0.0001063791,0.0003770436,0.00003708641,0.0003185229,0.9079429,0.0006281094,0.002260193,0.08337723],"study_design_scores_gemma":[0.0003355164,0.002352873,0.03320607,0.0001349248,0.0003704394,0.002088981,0.00007663545,0.001977638,0.8809406,0.0006523531,0.07783742,0.00002667349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7440889,0.2172742,0.01770068,0.003922404,0.0005769978,0.0002721724,0.001459433,0.001058037,0.01364714],"genre_scores_gemma":[0.9324022,0.05162863,0.004607736,0.0005786669,0.0001043388,0.0001406133,0.001696939,0.00004532691,0.008795474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002755084,"threshold_uncertainty_score":0.009216666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05353979808879243,"score_gpt":0.326557526758894,"score_spread":0.2730177286701016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}