{"id":"W1967949819","doi":"10.1371/journal.pone.0013465","title":"Regulation of STIM1 and SOCE by the Ubiquitin-Proteasome System (UPS)","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; University of California, San Diego; National Institutes of Health; University of Ottawa","keywords":"STIM1; Cell biology; Endoplasmic reticulum; Proteasome; Ubiquitin; HEK 293 cells; Thapsigargin; Biology; Neurite; Hippocampal formation; Chemistry; Cell culture; Biochemistry; Neuroscience; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847652,0.0004150969,0.0002852886,0.0003193954,0.00026714,0.0005392144,0.00009813571,0.0001937589,0.001617278],"category_scores_gemma":[0.0001174325,0.0001010802,0.0004559029,0.0001827236,0.0002384755,0.0002946536,0.0005075553,0.000300696,0.000503012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005137395,"about_ca_system_score_gemma":0.0001994756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005167747,"about_ca_topic_score_gemma":0.0008677503,"domain_scores_codex":[0.9997906,0.00003163955,0.00002494639,0.00004349488,0.00004688995,0.00006258045],"domain_scores_gemma":[0.99991,0.000009270678,0.00003075508,0.000009476326,0.00001690738,0.00002353675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002083745,0.00002677804,0.001492435,0.0002016616,0.0000308064,0.0002014993,0.00004185666,0.0001766085,0.98823,0.000595824,0.0003085953,0.008485577],"study_design_scores_gemma":[0.00002127497,0.0002517538,0.05108123,0.00002445723,0.00004454352,0.001033602,0.0000954466,0.002485301,0.9311369,0.0003136658,0.01349484,0.00001696698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966974,0.02204787,0.004581154,0.0003057342,0.00009364459,0.00005720973,0.001390068,0.0002128159,0.00433754],"genre_scores_gemma":[0.988489,0.004995177,0.002128625,0.0001200851,0.00002160647,0.00004495486,0.000919501,0.00001588332,0.003265242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617278,"threshold_uncertainty_score":0.005410373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03707138785329388,"score_gpt":0.2185015423943502,"score_spread":0.1814301545410563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}