{"id":"W1967959358","doi":"10.1016/j.bmcl.2014.11.047","title":"Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; National Institute of Mental Health","keywords":"Pharmacophore; Chemistry; Neurotensin; Agonist; G protein-coupled receptor; Receptor; Chemical synthesis; Stereochemistry; Pharmacology; Partial agonist; Structure–activity relationship; Neurotensin receptor; Biochemistry; In vitro; Neuropeptide; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007888067,0.0002882077,0.0002514921,0.0001838333,0.0001170155,0.0001480484,0.0003027537,0.0002780813,0.00142768],"category_scores_gemma":[0.0001254763,0.0001051771,0.0001477071,0.00007795357,0.0001384987,0.0001507291,0.000157577,0.0002036634,0.0005284615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002377635,"about_ca_system_score_gemma":0.0001981341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000666844,"about_ca_topic_score_gemma":0.0009793334,"domain_scores_codex":[0.9999464,0.000007819183,0.000002988241,0.00001219423,0.00001317889,0.00001744444],"domain_scores_gemma":[0.9999467,0.000008296859,0.00001351726,0.000003312898,0.000009555921,0.00001872301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002133821,0.00001684721,0.0001534328,0.0000251525,0.000002104329,0.000164088,0.00001082621,0.00005031093,0.9973971,0.00005271504,0.00004999396,0.001864051],"study_design_scores_gemma":[0.0001906571,0.001625182,0.01063466,0.00001096402,0.00002529264,0.002677488,0.00004697121,0.001533309,0.9755347,0.0001089365,0.007593259,0.00001877325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894427,0.002067678,0.00415823,0.0001880729,0.00005065786,0.0000720176,0.0005499942,0.00008232312,0.003388337],"genre_scores_gemma":[0.9892347,0.0009395801,0.004437913,0.0001641514,0.00002948546,0.00005397767,0.001063053,0.00001534097,0.004061712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142768,"threshold_uncertainty_score":0.004776061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183853712401779,"score_gpt":0.2515110958124164,"score_spread":0.2296725586883986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}