{"id":"W1967983050","doi":"10.1089/10430340252769743","title":"Superior Tissue-Specific Expression from Tyrosinase and Prostate-Specific Antigen Promoters/Enhancers in Helper-Dependent Compared with First-Generation Adenoviral Vectors","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research","keywords":"Enhancer; Promoter; Viral vector; Molecular biology; Biology; Genetic enhancement; LNCaP; Adenoviridae; Luciferase; Transduction (biophysics); Cell culture; Gene expression; Gene; Transfection; Prostate cancer; Recombinant DNA; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001752811,0.0003643329,0.0002998372,0.0001351739,0.000302807,0.0001441023,0.0002804987,0.0001665043,0.0005424412],"category_scores_gemma":[0.000002647143,0.0003206282,0.00004831065,0.0001529535,0.0001916327,0.00002342626,0.00006598857,0.0001706327,0.00002409415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007919329,"about_ca_system_score_gemma":0.00003334675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000721306,"about_ca_topic_score_gemma":0.0009483192,"domain_scores_codex":[0.997774,0.0001901798,0.0003323141,0.0008613509,0.0003617599,0.0004804047],"domain_scores_gemma":[0.9990426,0.00001055173,0.00009333401,0.000630829,0.00007641703,0.0001462157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00249661,0.0002289171,0.001809799,0.000007257025,0.0000359668,0.00003305267,0.001753289,0.0001714736,0.9888962,9.829247e-7,0.0007575644,0.003808868],"study_design_scores_gemma":[0.003671271,0.00420048,0.00365243,0.00003892103,0.000002563806,0.000007791278,0.0001410014,0.00007931294,0.9821504,0.000008299769,0.005625402,0.0004221296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786336,0.02001471,0.00008022645,0.0001034489,0.0000832189,0.0009581328,0.00005250279,0.0000320769,0.00004208006],"genre_scores_gemma":[0.9878985,0.01030369,0.0003806772,0.00007101387,0.0004078442,0.0001475126,0.0004285811,0.00008761431,0.0002745469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009711022,"threshold_uncertainty_score":0.9999246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04630855689589151,"score_gpt":0.2739538713367722,"score_spread":0.2276453144408807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}