{"id":"W1967983050","doi":"10.1089/10430340252769743","title":"Superior Tissue-Specific Expression from Tyrosinase and Prostate-Specific Antigen Promoters/Enhancers in Helper-Dependent Compared with First-Generation Adenoviral Vectors","year":2002,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research","keywords":"Enhancer; Promoter; Viral vector; Molecular biology; Biology; Genetic enhancement; LNCaP; Adenoviridae; Luciferase; Transduction (biophysics); Cell culture; Gene expression; Gene; Transfection; Prostate cancer; Recombinant DNA; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006212306,0.0004160481,0.0004608239,0.0003687719,0.0001457444,0.000708318,0.000362046,0.0002643399,0.0007496683],"category_scores_gemma":[0.0003378538,0.0002574648,0.0003577605,0.0002524607,0.0003204776,0.0004520922,0.0003228644,0.001140062,0.0004105083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785159,"about_ca_system_score_gemma":0.0003496202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005955047,"about_ca_topic_score_gemma":0.001251785,"domain_scores_codex":[0.9996094,0.00004929226,0.00004048852,0.00008082092,0.0001305021,0.00008946018],"domain_scores_gemma":[0.9997225,0.0000746362,0.00005636986,0.0000466343,0.00004224472,0.00005761237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006676061,0.00002936777,0.0001517028,0.00004811261,0.000003264367,0.00001658165,0.00001810359,0.00005061072,0.9980838,0.0001146619,0.0000180713,0.001398977],"study_design_scores_gemma":[0.000008142263,0.0002036137,0.001196838,0.000004906526,0.00001130217,0.0001854217,0.00001275817,0.0004276702,0.9954506,0.00003588926,0.002457834,0.000005046027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637268,0.003779302,0.02898361,0.00007396523,0.00009150139,0.0001126571,0.0006402934,0.0002838732,0.002307897],"genre_scores_gemma":[0.9545533,0.002808339,0.03391317,0.000059793,0.00002247562,0.00007143262,0.002288152,0.0001264073,0.006156755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007496683,"threshold_uncertainty_score":0.003285408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04630855689589151,"score_gpt":0.2739538713367722,"score_spread":0.2276453144408807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}