{"id":"W1967986514","doi":"10.1016/j.cell.2007.04.042","title":"Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination","year":2007,"lang":"en","type":"article","venue":"Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Western University; Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Research Resources","keywords":"Biology; Ubiquitin; Dimer; Yeast; Lysine; Protein–protein interaction; Signal transducing adaptor protein; Plasma protein binding; Substrate (aquarium); Cell biology; Biochemistry; Biophysics; Amino acid; Phosphorylation; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350414,0.0004444786,0.0004220452,0.0001913548,0.0009157023,0.001024576,0.0005142502,0.0003453403,0.005895001],"category_scores_gemma":[0.0002660098,0.0004080785,0.0002423581,0.0002253289,0.0003601848,0.0004292435,0.000690809,0.0007804303,0.00171272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006861845,"about_ca_system_score_gemma":0.0008047593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001207735,"about_ca_topic_score_gemma":0.002989912,"domain_scores_codex":[0.9998548,0.00001299119,0.000007646782,0.00003115138,0.00004149362,0.00005194232],"domain_scores_gemma":[0.9998492,0.0000122161,0.0000222863,0.00003736911,0.00002269603,0.00005621271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005032073,0.00005770821,0.002224473,0.00005919042,0.00001244028,0.0004824009,0.00006401194,0.001924048,0.9747579,0.006261835,0.001008898,0.01264388],"study_design_scores_gemma":[0.00009024102,0.0002729407,0.006841627,0.00001207292,0.00002831653,0.00134436,0.0004317594,0.0151499,0.9607117,0.00204087,0.01300515,0.00007116236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762695,0.0004698175,0.01365408,0.0002692681,0.00009589911,0.00001513411,0.0001425815,0.0003365023,0.008747188],"genre_scores_gemma":[0.9945469,0.0001271256,0.003501809,0.00005098138,0.000007374196,0.000006350579,0.0001274511,0.00004926035,0.001582916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005895001,"threshold_uncertainty_score":0.01972067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559079686831832,"score_gpt":0.2565993591578892,"score_spread":0.2410085622895709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}