{"id":"W1968020384","doi":"10.1074/jbc.m300847200","title":"Defining the Involvement of p38α MAPK in the Production of Anti- and Proinflammatory Cytokines Using an SB 203580-resistant Form of the Kinase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Proinflammatory cytokine; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Cytokine; Tumor necrosis factor alpha; Biology; Cell biology; Kinase; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008822977,0.00009742843,0.0001897977,0.00001257884,0.00004560011,0.000005241265,0.0002232807,0.0001097585,0.000004006008],"category_scores_gemma":[0.0003755329,0.00004266061,0.00009428411,0.00007886498,0.0002125281,0.00000543251,0.00005351223,0.0001321568,1.850277e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009265517,"about_ca_system_score_gemma":0.00008568533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005018557,"about_ca_topic_score_gemma":0.000003735953,"domain_scores_codex":[0.9990719,0.0001128978,0.000446117,0.0001173769,0.0001413313,0.000110369],"domain_scores_gemma":[0.9990572,0.00002765337,0.0005452364,0.0002279796,0.0001167984,0.00002512264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008501328,0.0001142854,0.02021032,0.00008844137,0.00001990138,0.000002277812,0.0001167482,0.00002266492,0.9790988,0.0001191021,0.00001931783,0.0001031448],"study_design_scores_gemma":[0.0002339019,0.0002328161,0.01554021,0.00007711323,0.00002093327,0.00008555326,0.0009581277,0.000005651181,0.9822283,0.000224457,0.000338748,0.00005414046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998241,0.001402926,0.00001250015,0.00006213187,0.00005454004,0.0001069541,0.000006529897,6.411976e-7,0.0001127656],"genre_scores_gemma":[0.9995116,0.0001421109,0.0002369982,0.00002332121,0.00007060028,0.000002068321,0.000002683071,0.00000381783,0.000006789759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004670109,"threshold_uncertainty_score":0.1739649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0256076761310442,"score_gpt":0.243879589841225,"score_spread":0.2182719137101808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}