{"id":"W1968042102","doi":"10.1007/s11033-008-9356-7","title":"Dual role of shikonin in early and late stages of collagen type II arthritis","year":2008,"lang":"en","type":"article","venue":"Molecular Biology Reports","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Arthritis; Cartilage; Messenger RNA; Tumor necrosis factor alpha; Cytokine; Type II collagen; Medicine; Collagen-induced arthritis; Interleukin; Immunology; Inflammation; Endocrinology; Andrology; Internal medicine; Chemistry; Anatomy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639844,0.0003446563,0.0002657429,0.0004193042,0.0001743753,0.0003713538,0.0001555267,0.0003163042,0.0009883139],"category_scores_gemma":[0.0001459419,0.000146193,0.0002482914,0.0001287362,0.0003139515,0.0005486669,0.0002355285,0.0004620529,0.0002807948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881045,"about_ca_system_score_gemma":0.0002592097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003647463,"about_ca_topic_score_gemma":0.0005975168,"domain_scores_codex":[0.9998777,0.00002385072,0.00001171899,0.0000154897,0.00002300435,0.00004821596],"domain_scores_gemma":[0.9997889,0.00002857779,0.00004904413,0.00002028143,0.00004255075,0.00007068662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000616057,0.00001987486,0.00101069,0.00006237056,0.000005215136,0.0002142483,0.00001984208,0.00002158691,0.9951024,0.0003080157,0.0000275917,0.002592133],"study_design_scores_gemma":[0.0001068521,0.001503303,0.08531987,0.00003510193,0.00009700646,0.002104882,0.0003402696,0.0005541459,0.9038687,0.001197548,0.004849756,0.00002241804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976401,0.01749547,0.00301458,0.0002195997,0.00007904738,0.00002171441,0.0001681236,0.00007595041,0.002524422],"genre_scores_gemma":[0.9943961,0.001959573,0.0009517429,0.00003425268,0.00004213775,0.00001314784,0.0001188292,0.000007432295,0.002476956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009883139,"threshold_uncertainty_score":0.00330621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04702096478622669,"score_gpt":0.3705367066876031,"score_spread":0.3235157419013764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}