{"id":"W1968055316","doi":"10.1016/j.ejps.2014.09.008","title":"Hyaluronan as drug carrier. The in vitro efficacy and selectivity of Hyaluronan–Doxorubicin complexes to affect the viability of overexpressing CD44 receptor cells","year":2014,"lang":"en","type":"article","venue":"European Journal of Pharmaceutical Sciences","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fondo para la Investigación Científica y Tecnológica; Queen's University","keywords":"CD44; Chemistry; A549 cell; Doxorubicin; Internalization; Flow cytometry; Hyaluronic acid; In vitro; Receptor; Cytotoxicity; Drug delivery; Biophysics; Cell culture; Biochemistry; Stereochemistry; Molecular biology; Biology; Medicine; Chemotherapy; Organic chemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490593,0.0002925581,0.0002366071,0.0001036708,0.0001535836,0.0002308769,0.0001596065,0.0002430485,0.0009747429],"category_scores_gemma":[0.0001500092,0.0001065081,0.0001406404,0.0001324508,0.0001705423,0.0002518105,0.0001227647,0.0003523899,0.0002077947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003758449,"about_ca_system_score_gemma":0.0002632958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305827,"about_ca_topic_score_gemma":0.001601462,"domain_scores_codex":[0.9998375,0.00004277309,0.00001583054,0.00003407295,0.0000336419,0.00003616253],"domain_scores_gemma":[0.9998733,0.00004625975,0.00002227077,0.00001495138,0.00002119081,0.00002204446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336778,0.00003349856,0.00006294412,0.00003898004,0.000004156393,0.0000187258,0.000022374,0.00006911959,0.9986338,0.0001232186,0.00003708165,0.0008224326],"study_design_scores_gemma":[0.000009855071,0.0001604056,0.0003346869,0.000001388995,0.000007278777,0.00003665432,0.000003455993,0.0003010418,0.9985045,0.000006616502,0.0006324514,0.000001725498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932289,0.002531037,0.002634197,0.00008964469,0.00004461255,0.00003643522,0.000211929,0.00004102378,0.00118214],"genre_scores_gemma":[0.9939718,0.0007861507,0.001807745,0.0000285474,0.000009021196,0.00003717099,0.0002620495,0.00001464199,0.003082894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305827,"threshold_uncertainty_score":0.003260851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02614299477300891,"score_gpt":0.3377038781263946,"score_spread":0.3115608833533857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}