{"id":"W1968094240","doi":"10.1021/jo026242u","title":"Synthesis and Growth Inhibitory Activity of Chiral 5-Hydroxy-2-<i>N</i>-Acyl-(3<i>E</i>)-Sphingenines:  Ceramides with an Unusual Sphingoid Backbone","year":2002,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Ceramide; Diastereomer; Stereochemistry; Trifluoromethyl; Ketone; Sphingolipid; Structural isomer; Hydrolysate; Organic chemistry; Hydrolysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000524309,0.0002354741,0.0003718373,0.00002857395,0.0001141353,0.00002822794,0.000353926,0.0001386511,0.0001214805],"category_scores_gemma":[0.0003095753,0.0001611965,0.00008968233,0.0001396389,0.0002477212,0.00003121995,0.0001031576,0.0002833179,6.884563e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001089766,"about_ca_system_score_gemma":0.00008412079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000151907,"about_ca_topic_score_gemma":0.000002600912,"domain_scores_codex":[0.9988247,0.00008137912,0.000381797,0.0001973458,0.0002827305,0.0002320922],"domain_scores_gemma":[0.9987312,0.00006684886,0.0005149115,0.0003270572,0.0001771914,0.0001827992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003445864,0.0001251622,0.00102423,0.00008622737,0.0001425739,0.00000528402,0.0002639837,0.00001602454,0.9974197,0.000001906388,0.00009169555,0.0004786401],"study_design_scores_gemma":[0.0007873746,0.000204039,0.001215591,0.00006365516,0.0001955431,0.0005471833,0.0002571392,0.00005899926,0.9963325,0.00001905795,0.0001208474,0.0001980459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965182,0.002661762,0.0002799332,0.0001517589,0.00006161839,0.00005467372,0.000007489037,0.000007467904,0.0002571022],"genre_scores_gemma":[0.9976214,0.001050961,0.0003206286,0.00008076259,0.000785902,0.000001123701,0.000001852366,0.00004061712,0.00009673504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001610801,"threshold_uncertainty_score":0.6573405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008026317419794395,"score_gpt":0.1972477845472408,"score_spread":0.1892214671274464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}