{"id":"W1968094240","doi":"10.1021/jo026242u","title":"Synthesis and Growth Inhibitory Activity of Chiral 5-Hydroxy-2-<i>N</i>-Acyl-(3<i>E</i>)-Sphingenines:  Ceramides with an Unusual Sphingoid Backbone","year":2002,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Heart, Lung, and Blood Institute","keywords":"Chemistry; Ceramide; Diastereomer; Stereochemistry; Trifluoromethyl; Ketone; Sphingolipid; Structural isomer; Hydrolysate; Organic chemistry; Hydrolysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044265,0.0003746322,0.000159489,0.0001623067,0.0001041949,0.0001718548,0.0001918831,0.0001658858,0.0007791679],"category_scores_gemma":[0.0001422306,0.0000874668,0.0001547582,0.0001354575,0.000131236,0.0001625976,0.0001582825,0.0002991839,0.0003875611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364195,"about_ca_system_score_gemma":0.0002847152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007180236,"about_ca_topic_score_gemma":0.0009594018,"domain_scores_codex":[0.9999381,0.00001028847,0.000005790053,0.000009241738,0.00001790511,0.00001861382],"domain_scores_gemma":[0.9999288,0.000009804139,0.00001362498,0.000009067397,0.000009532322,0.00002916064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012787,0.0000343873,0.00009197536,0.00004133282,0.00000431363,0.00009476773,0.00001502521,0.0001941793,0.9957446,0.0001613048,0.00004989538,0.0033669],"study_design_scores_gemma":[0.00001332692,0.0001765435,0.0002894918,0.000001946455,0.000006394961,0.0001010689,0.000006059677,0.0001273172,0.9980174,0.00002286848,0.001235134,0.000002371158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861482,0.005837215,0.00285858,0.00009854486,0.0000466383,0.00004715063,0.0007959994,0.00006895987,0.004098675],"genre_scores_gemma":[0.9914036,0.003000312,0.002543559,0.00003962946,0.00001623182,0.00002272111,0.0009864371,0.0000200814,0.001967454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007791679,"threshold_uncertainty_score":0.00260663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008026317419794395,"score_gpt":0.1972477845472408,"score_spread":0.1892214671274464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}