{"id":"W1968114995","doi":"10.1074/jbc.m110.194266","title":"Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Hygromycin B; Enzyme; Function (biology); Chemistry; Biology; Genetics; Molecular biology; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002469371,0.0001011302,0.0002262018,0.00001773869,0.00004369465,0.00001859423,0.000133936,0.0002299192,0.0009857384],"category_scores_gemma":[0.0002235742,0.00006299122,0.0000617624,0.00006996132,0.000169373,0.00008372105,0.00003042026,0.0003474948,0.000001067426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009284401,"about_ca_system_score_gemma":0.00002786308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001425752,"about_ca_topic_score_gemma":0.000003716597,"domain_scores_codex":[0.9992307,0.00002227941,0.0003370865,0.0001366076,0.0001539114,0.0001194507],"domain_scores_gemma":[0.9992086,0.00006698625,0.0003879979,0.0001197985,0.0001359686,0.00008063459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108885,0.00001322915,0.001559017,0.00003690804,0.000006865733,0.000004600702,0.00001627627,0.00000156202,0.9972254,0.00008707205,0.0005010475,0.0003371226],"study_design_scores_gemma":[0.0002815427,0.0001062907,0.0135583,0.00001897154,0.00001708927,0.0001088753,0.0000317267,0.000001387654,0.9794972,0.003332266,0.002971568,0.00007476666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981248,0.000351065,0.0001653427,0.0000844576,0.0003950378,0.00002412983,0.00001707843,0.000008845908,0.0008292589],"genre_scores_gemma":[0.9977487,0.00002219221,0.00156458,0.00004563137,0.0004759749,3.814499e-7,0.000002483308,0.000003774033,0.0001363356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01772819,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008953900338334583,"score_gpt":0.224775472382597,"score_spread":0.2158215720442624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}