{"id":"W1968152740","doi":"10.1074/jbc.m115.640169","title":"Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity Western University","funders":"","keywords":"Chemokine receptor; CCR5 receptor antagonist; Peptide sequence; CCR2; Transmembrane domain; Chemokine; Molecular biology; Biochemistry; Chemistry; Amino acid; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425004,0.0005412503,0.0005113707,0.0001363874,0.0001751283,0.0003205531,0.0004136287,0.0003703673,0.002269643],"category_scores_gemma":[0.0001608965,0.0001928907,0.0003549764,0.0001364593,0.0002344687,0.0001385311,0.0002407898,0.0007616038,0.001074625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003001513,"about_ca_system_score_gemma":0.0003590991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005174344,"about_ca_topic_score_gemma":0.001121754,"domain_scores_codex":[0.9995828,0.0000707154,0.00003886972,0.00007988467,0.0001352167,0.00009249937],"domain_scores_gemma":[0.9998924,0.0000218629,0.00002272998,0.00002313172,0.00001675229,0.00002301619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008119268,0.00003866239,0.00006684686,0.00003026672,0.000009208617,0.0000294664,0.000005738886,0.00004998092,0.9982321,0.00009481221,0.00005962386,0.001302276],"study_design_scores_gemma":[0.00004551173,0.0004841255,0.001024451,0.000005353805,0.0000184565,0.0003645784,0.00000447471,0.0005094606,0.9924745,0.00001515011,0.005046992,0.000006833028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743758,0.004364855,0.01031251,0.0002515577,0.0001636825,0.000342438,0.0009749919,0.0003109453,0.008903101],"genre_scores_gemma":[0.9766368,0.001618874,0.01378557,0.000169084,0.00003702711,0.0002168599,0.001831677,0.00004537072,0.005658736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002269643,"threshold_uncertainty_score":0.007592738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07749936288302367,"score_gpt":0.2942877689834462,"score_spread":0.2167884061004225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}