{"id":"W1968180930","doi":"10.1038/onc.2012.472","title":"RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cancer Research Society; Dartmouth College","keywords":"Biology; DNA damage; Melanoma; MAPK/ERK pathway; CHEK1; Cancer research; Kinase; Protein kinase A; G2-M DNA damage checkpoint; Gene silencing; Ribosomal s6 kinase; Cell biology; Signal transduction; Cancer; DNA; Cell cycle checkpoint; Cell cycle; Genetics; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633102,0.0004326325,0.0001962077,0.0003434466,0.0002254447,0.0004740023,0.0002419452,0.0002772805,0.003060631],"category_scores_gemma":[0.0001595269,0.000206009,0.0004020626,0.000167489,0.0002439763,0.0002402515,0.0002916071,0.0006039085,0.00127839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432298,"about_ca_system_score_gemma":0.0002211132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004298888,"about_ca_topic_score_gemma":0.0005523039,"domain_scores_codex":[0.9998939,0.00002061961,0.000009102082,0.00002009574,0.00002279114,0.00003350598],"domain_scores_gemma":[0.9999182,0.000007835967,0.00002927078,0.0000165682,0.000008177239,0.00001981161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004022076,0.00005406145,0.0007202624,0.00005861161,0.00001370935,0.0001059085,0.00001077739,0.0001803209,0.9955475,0.00058461,0.000235475,0.00208644],"study_design_scores_gemma":[0.00006568225,0.0002214891,0.0168814,0.00001004546,0.00004079257,0.0006491521,0.00004622122,0.002287792,0.9740864,0.0003478653,0.005351594,0.00001167049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913926,0.002363953,0.002182135,0.0002886557,0.00005300846,0.00002072514,0.0003543801,0.0002710979,0.003073334],"genre_scores_gemma":[0.9954763,0.0006498226,0.0004866378,0.00003786683,0.000009976624,0.00001454907,0.0002603504,0.00002827572,0.003036194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003060631,"threshold_uncertainty_score":0.01023889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628789380749476,"score_gpt":0.247591857482262,"score_spread":0.2313039636747672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}