{"id":"W1968180930","doi":"10.1038/onc.2012.472","title":"RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cancer Research Society; Dartmouth College","keywords":"Biology; DNA damage; Melanoma; MAPK/ERK pathway; CHEK1; Cancer research; Kinase; Protein kinase A; G2-M DNA damage checkpoint; Gene silencing; Ribosomal s6 kinase; Cell biology; Signal transduction; Cancer; DNA; Cell cycle checkpoint; Cell cycle; Genetics; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002823476,0.0001494938,0.0001599116,0.00003065815,0.00004719192,0.00001515551,0.0000950832,0.0001116059,0.00003009997],"category_scores_gemma":[0.00008213992,0.0001383394,0.00003849926,0.0000666028,0.00005272299,0.000008180287,0.0001025997,0.00006170677,0.00001421661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001584091,"about_ca_system_score_gemma":0.00003351409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002670588,"about_ca_topic_score_gemma":0.0001078896,"domain_scores_codex":[0.9990407,0.0000433766,0.0001951511,0.0002532608,0.00008329166,0.0003842658],"domain_scores_gemma":[0.9995188,0.00001127715,0.0000604457,0.0002504277,0.00002257252,0.0001364835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002849006,0.00007521555,0.03738078,0.00003291079,0.00001260863,0.000006731542,0.0002402989,9.711431e-7,0.9607412,0.00007407439,0.0001277777,0.00127898],"study_design_scores_gemma":[0.0004071785,0.0001239172,0.03270572,0.00002229692,0.00001196387,0.00001486318,0.0001083367,0.00002968901,0.9628595,0.00005178294,0.003479208,0.0001855757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945071,0.002703899,0.00006133607,0.00007877791,0.00009585355,0.0001412299,0.00001158187,0.00001182052,0.002388417],"genre_scores_gemma":[0.9981256,0.00009865357,0.0009372745,0.00008865275,0.0002790098,0.00004007359,0.00004096072,0.00002031255,0.0003694557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004675068,"threshold_uncertainty_score":0.5641319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628789380749476,"score_gpt":0.247591857482262,"score_spread":0.2313039636747672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}