{"id":"W1968183881","doi":"10.1038/mt.2011.281","title":"Combined mTOR Inhibition and OX40 Agonism Enhances CD8+ T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Virology; Immunity; Recombinant DNA; Agonism; CD8; Biology; PI3K/AKT/mTOR pathway; Immunology; Immune system; Cell biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701611,0.0004070195,0.0002891294,0.0001954821,0.00007960656,0.0002239459,0.0001763578,0.0001681375,0.000852327],"category_scores_gemma":[0.00008287587,0.00009912021,0.0002263275,0.00007789562,0.0001768711,0.0001973993,0.000170196,0.000502708,0.0001726608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643509,"about_ca_system_score_gemma":0.0002081965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002457738,"about_ca_topic_score_gemma":0.0005821724,"domain_scores_codex":[0.999846,0.00003190203,0.00002131118,0.00002496767,0.00002289522,0.00005292325],"domain_scores_gemma":[0.9999436,0.00001000961,0.00001704582,0.000006411057,0.000005343883,0.00001752551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005847464,0.0001904544,0.0001643033,0.00008142103,0.00001152081,0.00002621592,0.00001506425,0.0001392549,0.9937837,0.00008474768,0.00004605617,0.004872464],"study_design_scores_gemma":[0.00009315625,0.003536007,0.002417708,0.00001058274,0.00005809988,0.0001231733,0.00002251038,0.0008879826,0.990922,0.00003555329,0.001888494,0.000004595958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972737,0.0008611005,0.0008416859,0.00004638345,0.00002726992,0.0000269578,0.00006748187,0.00004377602,0.0008115927],"genre_scores_gemma":[0.9969121,0.0005238194,0.001273679,0.00004155747,0.00001905149,0.00003955531,0.0001300405,0.000008484659,0.001051666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000852327,"threshold_uncertainty_score":0.002851307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204404968165576,"score_gpt":0.2091777085675677,"score_spread":0.1971336588859119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}