{"id":"W1968228690","doi":"10.1159/000354448","title":"Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization Following<b><i>Clostridium Difficile</i></b>Toxin Exposure of the Caco-2 Epithelial Cell Line","year":2013,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Clostridium difficile toxin A; Nitric oxide; Toxin; Clostridium difficile toxin B; Nitric oxide synthase; Caco-2; Reactive oxygen species; Chemistry; Microbiology; Biochemistry; In vitro; Cell biology; Biology; Clostridium difficile","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404395,0.0001968604,0.0001588234,0.0001006844,0.0001287677,0.0001279611,0.0001100638,0.0002186459,0.0007067245],"category_scores_gemma":[0.00009166227,0.00007431227,0.0001853063,0.0000898167,0.00015209,0.0001091831,0.00008366995,0.0002951391,0.0001272398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918124,"about_ca_system_score_gemma":0.0001400802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00068849,"about_ca_topic_score_gemma":0.0009653544,"domain_scores_codex":[0.9998996,0.00001977028,0.000008323595,0.0000191683,0.00002123507,0.00003184434],"domain_scores_gemma":[0.9999105,0.00001353897,0.00003273854,0.000007942774,0.00001585054,0.00001942328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002711166,0.0000265627,0.0001610508,0.00003694734,0.000003629685,0.00002152008,0.000008620966,0.0000195252,0.9989902,0.00001551251,0.00001884307,0.0004264158],"study_design_scores_gemma":[0.00001143252,0.0005137845,0.004975182,0.00000498166,0.0000116208,0.00009272314,0.000017392,0.00028297,0.9932414,0.00001099254,0.000834613,0.000002823553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955448,0.00208085,0.001179959,0.00009497931,0.00003255378,0.000020231,0.000212565,0.00002436966,0.0008096746],"genre_scores_gemma":[0.9957718,0.0008993623,0.001727136,0.00007896261,0.00001548596,0.00003623355,0.0004133636,0.000007277225,0.001050458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007067245,"threshold_uncertainty_score":0.002364278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006417860227745156,"score_gpt":0.2092440050662927,"score_spread":0.2028261448385475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}