{"id":"W1968228690","doi":"10.1159/000354448","title":"Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1a Stabilization Following<b><i>Clostridium Difficile</i></b>Toxin Exposure of the Caco-2 Epithelial Cell Line","year":2013,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Clostridium difficile toxin A; Nitric oxide; Toxin; Clostridium difficile toxin B; Nitric oxide synthase; Caco-2; Reactive oxygen species; Chemistry; Microbiology; Biochemistry; In vitro; Cell biology; Biology; Clostridium difficile","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136051,0.0002636964,0.0004991196,0.00006683182,0.000115264,0.000008772168,0.0001496055,0.0003011432,0.00005008508],"category_scores_gemma":[0.0002311133,0.0001832212,0.0001845087,0.0002842077,0.0004084587,0.00003118478,0.0001609919,0.0003621025,0.000004539571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004571588,"about_ca_system_score_gemma":0.0001085577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005041478,"about_ca_topic_score_gemma":3.806594e-7,"domain_scores_codex":[0.998548,0.00009634229,0.0003517341,0.0004248877,0.0002815139,0.0002974734],"domain_scores_gemma":[0.998783,0.0003229203,0.0001971681,0.0004100744,0.0001589022,0.0001279279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003213157,0.0004936178,0.0009060281,0.001028678,0.00008506478,0.000008300931,0.0000732651,0.000003118337,0.9967729,0.0000089962,0.0001186445,0.0001800789],"study_design_scores_gemma":[0.001629942,0.0004837316,0.01632723,0.0001514266,0.0001508405,0.000006612265,0.0002178269,0.00004044742,0.9807322,0.00005572745,0.0000471748,0.0001568464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99718,0.001600159,0.000004957098,0.0001768438,0.00006952869,0.0006067329,0.00003862428,0.00001631766,0.0003068264],"genre_scores_gemma":[0.9984164,0.0003580725,0.00002334409,0.00005097759,0.0001696931,0.00002601604,0.00007295984,0.00002301741,0.0008595827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0160407,"threshold_uncertainty_score":0.7471544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006417860227745156,"score_gpt":0.2092440050662927,"score_spread":0.2028261448385475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}