{"id":"W1968240102","doi":"10.1002/mus.20654","title":"Reliable surrogate outcome measures in multicenter clinical trials of Duchenne muscular dystrophy","year":2006,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré de Santé et Services Sociaux de Chaudière-Appalache","funders":"","keywords":"Duchenne muscular dystrophy; Intraclass correlation; Medicine; Physical therapy; Muscular dystrophy; Clinical trial; Ambulatory; Inter-rater reliability; Physical medicine and rehabilitation; Vital capacity; Surrogate endpoint; Internal medicine; Rating scale; Psychology; Psychometrics; Diffusing capacity; Lung function","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3959531,0.001402824,0.003670782,0.002152293,0.001339006,0.002515854,0.001430588,0.002556108,0.0008311301],"category_scores_gemma":[0.4804234,0.0008364696,0.002318098,0.003013992,0.002403014,0.002161815,0.002776326,0.002008696,0.0003026639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001339664,"about_ca_system_score_gemma":0.001745895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003019275,"about_ca_topic_score_gemma":0.0004806428,"domain_scores_codex":[0.4304578,0.5162691,0.03185258,0.006984247,0.01313803,0.001298216],"domain_scores_gemma":[0.4204548,0.3858359,0.1201373,0.0329163,0.03616314,0.004492494],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.195009,0.002920659,0.6021551,0.009452783,0.0327682,0.0003562939,0.003577401,0.009209523,0.002899532,0.004399458,0.00599256,0.1312595],"study_design_scores_gemma":[0.05243987,0.1618223,0.7069776,0.004658393,0.01217084,0.00109486,0.001343249,0.01977843,0.005043523,0.007912673,0.02623517,0.0005231923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8484102,0.07302303,0.04861666,0.003220398,0.001876151,0.01676599,0.002690027,0.000245701,0.005151819],"genre_scores_gemma":[0.9587275,0.001683999,0.01961324,0.0006853179,0.000479757,0.0168829,0.001625555,0.00004451843,0.0002571969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6040468,"threshold_uncertainty_score":0.7448973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06835478889089411,"score_gpt":0.364864273023369,"score_spread":0.2965094841324749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}