{"id":"W1968252106","doi":"10.1016/j.yjmcc.2007.03.791","title":"Chronic activation of cardioprotective cGMP signaling involves changes in energy substrate selection","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Université de Montréal; McGill University","funders":"","keywords":"Citric acid cycle; Glycolysis; Endocrinology; Flux (metallurgy); Chemistry; Internal medicine; Cardioprotection; Beta oxidation; Ex vivo; Biochemistry; Metabolism; Cell biology; Biology; Medicine; Ischemia; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005933818,0.0001126147,0.0002679423,0.0001790145,0.00003067221,0.000005714078,0.00005267265,0.0001990345,0.000001962799],"category_scores_gemma":[0.00003369147,0.0001033704,0.0001235399,0.0001284488,0.00006830523,0.000007810404,0.00002189057,0.0001197217,7.989339e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004446911,"about_ca_system_score_gemma":0.00006645224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002212296,"about_ca_topic_score_gemma":0.00004026526,"domain_scores_codex":[0.9991323,0.0001398093,0.0003051603,0.0001511658,0.0001151232,0.0001564483],"domain_scores_gemma":[0.9994106,0.00001450811,0.0002655922,0.00008076029,0.0001800585,0.00004848307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002375565,0.00001040719,0.002231403,0.000018653,0.0001364815,0.00002422593,0.00004167323,0.00585436,0.9866723,0.00008263899,0.000006924892,0.00468335],"study_design_scores_gemma":[0.0006401148,0.0006808387,0.003420601,0.00003068119,0.00003345535,0.0001354807,0.0001441999,0.00006464843,0.9931193,0.0001470681,0.001485043,0.00009857126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8727867,0.00367562,0.1231777,0.00004082924,0.0001458919,0.00007531743,8.312231e-7,0.000002003102,0.00009518084],"genre_scores_gemma":[0.9991348,0.0002896069,0.0001678995,0.00003826842,0.0003212752,0.000003208352,0.0000157673,0.00001136174,0.00001785848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1263481,"threshold_uncertainty_score":0.4215323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006897353074469694,"score_gpt":0.2091337828384106,"score_spread":0.2022364297639409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}