{"id":"W1968255867","doi":"10.1371/journal.pone.0006068","title":"A Genetic Screen in Drosophila Reveals Novel Cytoprotective Functions of the Autophagy-Lysosome Pathway","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; National Institutes of Health; American Cancer Society","keywords":"Autophagy; Lysosome; Biology; Cell biology; Genetic screen; Neurodegeneration; Autophagy-related protein 13; BAG3; ATG16L1; Programmed cell death; Schneider 2 cells; Gene; Genetics; Phenotype; RNA interference; Signal transduction; Biochemistry; RNA; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331144,0.0009132865,0.0002839583,0.000825304,0.0002931643,0.0002958809,0.0004118771,0.0004820275,0.0014315],"category_scores_gemma":[0.0001421423,0.0002723695,0.0004381663,0.0003464796,0.0002689699,0.0001132477,0.0002852491,0.0004340624,0.0005090762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005631069,"about_ca_system_score_gemma":0.0003793158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001752886,"about_ca_topic_score_gemma":0.004074092,"domain_scores_codex":[0.9998302,0.00002056853,0.00002536563,0.00004568711,0.0000554122,0.00002266694],"domain_scores_gemma":[0.9997972,0.00006511749,0.00005706633,0.00001873408,0.00001853471,0.0000433246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003049837,0.00001967156,0.0002125231,0.00003351648,0.00001035865,0.0002043657,0.00000807963,0.00009914794,0.9979626,0.0001389402,0.00004486409,0.001235602],"study_design_scores_gemma":[0.00005930416,0.0003412038,0.01341005,0.000023024,0.00009604081,0.001412073,0.00004385276,0.00260637,0.9768173,0.0000982505,0.005072051,0.00002057136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704809,0.001716284,0.01563671,0.0002309108,0.00004598238,0.0003404166,0.005454719,0.0007087055,0.005385545],"genre_scores_gemma":[0.9681114,0.00170987,0.01904115,0.0002146264,0.00001260566,0.0002170836,0.004567376,0.0001631123,0.00596279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752886,"threshold_uncertainty_score":0.004788816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03514962700772765,"score_gpt":0.2404545658999163,"score_spread":0.2053049388921886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}