{"id":"W1968299608","doi":"10.1210/en.2006-1300","title":"Combination Therapy with the Advanced Glycation End Product Cross-Link Breaker, Alagebrium, and Angiotensin Converting Enzyme Inhibitors in Diabetes: Synergy or Redundancy?","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"U.S. Public Health Service","keywords":"Endocrinology; Internal medicine; Advanced glycation end-product; Glycation; Diabetes mellitus; Ramipril; Albuminuria; Diabetic nephropathy; Angiotensin II; Oxidative stress; Medicine; Angiotensin-converting enzyme; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856804,0.0001919041,0.0001722723,0.00009739673,0.0001553865,0.00003526187,0.0001617108,0.0000796511,0.00001419588],"category_scores_gemma":[0.0001929548,0.0001340602,0.00002510548,0.0002694342,0.0004146374,0.0000262843,0.00008264888,0.0001882636,0.000003401406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003376244,"about_ca_system_score_gemma":0.00009614247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008231647,"about_ca_topic_score_gemma":0.0002114589,"domain_scores_codex":[0.9983674,0.0001699008,0.0002663224,0.0005801762,0.0001517712,0.0004644261],"domain_scores_gemma":[0.9991287,0.00006758783,0.0001415986,0.0004179726,0.0002099877,0.00003417715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007475147,0.0001515484,0.02699132,0.00002752144,0.00004622421,0.00001940825,0.0001423378,0.001296564,0.8748531,0.0009425571,0.0007078318,0.09407406],"study_design_scores_gemma":[0.002287009,0.0005538008,0.06737544,0.00001737049,0.00000495301,0.00007272392,0.00005883768,0.00009541699,0.8536437,0.0002672457,0.0753743,0.0002492707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881166,0.004073218,0.0001816816,0.006758159,0.0001239092,0.0005110443,0.000004892951,0.00002944999,0.0002010818],"genre_scores_gemma":[0.9964541,0.0005463754,0.0004647493,0.0002513089,0.0002971489,0.0001044122,0.0001508871,0.00003326109,0.001697724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09382479,"threshold_uncertainty_score":0.5466816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009028622733668319,"score_gpt":0.2702198205358457,"score_spread":0.2611911978021774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}