{"id":"W1968312985","doi":"10.1021/bi991938b","title":"Role for the C-Terminus in Agonist-Induced μ Opioid Receptor Phosphorylation and Desensitization","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse","keywords":"DAMGO; Enzyme-linked receptor; Homologous desensitization; Receptor; 5-HT5A receptor; Opioid receptor; Chemistry; Interleukin-21 receptor; Protease-activated receptor 2; Estrogen-related receptor alpha; Phosphorylation; Agonist; Biology; Cell biology; Molecular biology; Biochemistry; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761563,0.000347365,0.0002632516,0.0001440435,0.0002494367,0.0003187605,0.0003171056,0.0004072666,0.002089572],"category_scores_gemma":[0.0002511099,0.000168377,0.0004839321,0.000143774,0.0003037532,0.0004318735,0.0002613849,0.0004627092,0.0007347027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005341361,"about_ca_system_score_gemma":0.0003205708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007385302,"about_ca_topic_score_gemma":0.0006976268,"domain_scores_codex":[0.9998848,0.00001849957,0.00001560681,0.00002809523,0.00002900455,0.00002397435],"domain_scores_gemma":[0.9997901,0.00004099683,0.00008517732,0.0000246129,0.00002577882,0.00003330525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000150429,0.00001101163,0.0001393861,0.00003039448,0.000003263034,0.00008208772,0.000007770564,0.00005065136,0.9989911,0.0001103593,0.000009782398,0.0004138164],"study_design_scores_gemma":[0.00003278788,0.000148815,0.01376192,0.0000189566,0.00002061722,0.001132485,0.00004904819,0.001313648,0.9816551,0.0001817096,0.001672302,0.00001270564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945094,0.001603543,0.002219311,0.0001097517,0.00001713446,0.00003004545,0.0002585634,0.00002275301,0.001229459],"genre_scores_gemma":[0.9925702,0.001388591,0.003432395,0.00009480261,0.00001093477,0.00003594604,0.0007431036,0.00001951208,0.001704606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002089572,"threshold_uncertainty_score":0.006990254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412767501125018,"score_gpt":0.2256527598226857,"score_spread":0.2182399923215607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}