{"id":"W1968312985","doi":"10.1021/bi991938b","title":"Role for the C-Terminus in Agonist-Induced μ Opioid Receptor Phosphorylation and Desensitization","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse","keywords":"DAMGO; Enzyme-linked receptor; Homologous desensitization; Receptor; 5-HT5A receptor; Opioid receptor; Chemistry; Interleukin-21 receptor; Protease-activated receptor 2; Estrogen-related receptor alpha; Phosphorylation; Agonist; Biology; Cell biology; Molecular biology; Biochemistry; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282117,0.0001066232,0.00007647422,0.000009536577,0.00009599936,0.00003384833,0.00008088024,0.0001507785,0.0001039556],"category_scores_gemma":[0.00003512856,0.00009091503,0.00004012768,0.00004736325,0.0000256627,0.00000304829,0.00001894576,0.0000491329,0.000003188833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001438334,"about_ca_system_score_gemma":0.00003821402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001803675,"about_ca_topic_score_gemma":0.000005720449,"domain_scores_codex":[0.9993872,0.00001249792,0.0001372191,0.0002502008,0.00006231025,0.0001505564],"domain_scores_gemma":[0.9997023,0.00001731717,0.00003770222,0.0001701898,0.00003404336,0.00003842359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007294075,0.00001437949,0.00008904447,0.00001268566,0.000007895438,2.884734e-7,0.00004228754,0.00002255982,0.9653259,0.000009062109,0.0002365353,0.03416644],"study_design_scores_gemma":[0.0003474558,0.00005023211,0.0002131497,0.00001547888,0.00000616473,0.000006873199,0.0001049563,0.001009858,0.9896492,0.00006228997,0.008410785,0.0001235201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980686,0.0008155918,0.0004022364,0.00007573598,0.00004922395,0.0002790984,0.00001365478,0.000008325627,0.0002875241],"genre_scores_gemma":[0.997588,0.0002037334,0.0006237579,0.00009555077,0.0002426072,0.00008003981,0.0001783439,0.00001634584,0.0009716607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03404292,"threshold_uncertainty_score":0.3707407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007412767501125018,"score_gpt":0.2256527598226857,"score_spread":0.2182399923215607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}