{"id":"W1968319279","doi":"10.1097/fpc.0000000000000031","title":"Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption","year":2014,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"CYP2A6; Nicotine; Monooxygenase; Metabolite; Metabolism; Chemistry; Cotinine; Cytochrome P450; Drug metabolism; Biochemistry; Pharmacology; Biology; Internal medicine; CYP1A2; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001466258,0.0005412058,0.0006535251,0.0004040475,0.0002837762,0.0001188466,0.0002363699,0.0003172835,0.0001860165],"category_scores_gemma":[0.0000705941,0.0004948029,0.00007398347,0.0002589487,0.0002400019,0.0001791674,0.0001658045,0.000778919,0.000009826352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001358604,"about_ca_system_score_gemma":0.0001172117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002139484,"about_ca_topic_score_gemma":0.0003663055,"domain_scores_codex":[0.9966494,0.000645167,0.0008782718,0.0008210876,0.0002366744,0.0007693723],"domain_scores_gemma":[0.9984326,0.0003352996,0.0003709569,0.0002537976,0.000153208,0.0004541574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024305,0.0004713676,0.02012468,0.00006840273,0.0003822494,0.00003888264,0.004790022,0.002665961,0.9558686,0.0005267622,0.00005653616,0.01398222],"study_design_scores_gemma":[0.01631656,0.000196569,0.1409848,0.00005629374,0.001218581,0.00005380241,0.0002076253,0.1812904,0.646312,0.0008595849,0.0111355,0.001368263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932004,0.003218956,0.0003044741,0.0009723128,0.0006307709,0.0008148889,0.0006765818,0.000041829,0.0001398018],"genre_scores_gemma":[0.9878309,0.006080383,0.0007281385,0.004500358,0.0003714072,0.0001212513,0.0001376288,0.00007357731,0.0001563572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3095566,"threshold_uncertainty_score":0.9997504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835469404427228,"score_gpt":0.3456313863337212,"score_spread":0.2972766922894489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}