{"id":"W1968328048","doi":"10.1016/j.tips.2009.10.001","title":"The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters","year":2009,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":223,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Drug; Pharmacology; Antiretroviral drug; ATP-binding cassette transporter; Drug interaction; Efflux; Pharmacokinetics; Transporter; Human immunodeficiency virus (HIV); Drug metabolism; Antiretroviral therapy; Medicine; Virology; Biology; Viral load; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005364264,0.0002465191,0.001070071,0.0003271324,0.0001447358,0.00001554057,0.000261641,0.00004201004,0.0002726171],"category_scores_gemma":[0.00001322863,0.0001192854,0.0002401793,0.0007801198,0.001159094,0.00007646362,0.00003575128,0.0002520618,0.000002315675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005900418,"about_ca_system_score_gemma":0.0001068269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003192534,"about_ca_topic_score_gemma":0.00003962445,"domain_scores_codex":[0.9982887,0.0001440444,0.0006904667,0.0003083135,0.0003004675,0.0002680243],"domain_scores_gemma":[0.9990897,0.0004246497,0.0003021314,0.00008125725,0.00002411549,0.00007814444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000336904,0.0002285959,0.001353239,0.0003142408,0.000103521,0.00001390799,0.0003457862,4.270777e-7,0.000009432334,0.0003833006,0.0006729896,0.9965408],"study_design_scores_gemma":[0.001168169,0.0004438617,0.004145849,0.003893033,0.00150875,0.00005298067,0.001023206,0.00007133907,0.0001472483,0.0006019879,0.986603,0.0003405911],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008949215,0.9796591,2.836107e-7,0.0006159544,0.0001305537,0.0003066291,0.00002489085,0.00001904126,0.01029427],"genre_scores_gemma":[0.0657215,0.9309793,0.0002664537,0.00002707312,0.0000392574,0.00003539756,0.00002301726,0.000004791296,0.002903192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962003,"threshold_uncertainty_score":0.4864316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08393546633828616,"score_gpt":0.4171650216645466,"score_spread":0.3332295553262604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}