{"id":"W1968336312","doi":"10.1089/scd.2012.0218","title":"The Generation of Definitive Neural Stem Cells from <i>PiggyBac</i> Transposon-Induced Pluripotent Stem Cells Can Be Enhanced by Induction of the NOTCH Signaling Pathway","year":2012,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Mount Sinai Hospital; University of Regina; Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Neurotrauma Foundation","keywords":"Biology; Induced pluripotent stem cell; Noggin; Neurosphere; Neural stem cell; Embryonic stem cell; Cell biology; Notch signaling pathway; Leukemia inhibitory factor; Stem cell; Induced stem cells; Neural development; Bone morphogenetic protein; Adult stem cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191871,0.0005093985,0.0002797119,0.0002732195,0.0001062747,0.0002901761,0.000287534,0.0003447475,0.001447595],"category_scores_gemma":[0.0001402391,0.0001841828,0.0003441764,0.000146824,0.0002633764,0.000203785,0.0003509061,0.0006579888,0.0008010242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906277,"about_ca_system_score_gemma":0.0002248083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003465064,"about_ca_topic_score_gemma":0.0006244185,"domain_scores_codex":[0.9998754,0.00001128417,0.00002144548,0.00002707867,0.00005138765,0.00001341166],"domain_scores_gemma":[0.9999086,0.00001726337,0.00002432103,0.00002021594,0.00001282837,0.00001671499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001257011,0.000005890162,0.00006763761,0.0000349432,0.000002628825,0.00004164725,0.000008763253,0.00005233344,0.9980392,0.000163375,0.00004289165,0.001528139],"study_design_scores_gemma":[0.000005151903,0.0000902,0.001294895,0.000009311451,0.00001196288,0.0002438891,0.000008087352,0.0005752559,0.9931355,0.00009054508,0.004530875,0.000004308633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8736435,0.002405745,0.1060755,0.0002750193,0.0002471634,0.0003718023,0.00356826,0.001637301,0.01177577],"genre_scores_gemma":[0.9241021,0.002874098,0.05434978,0.0001978463,0.00003064215,0.0002407235,0.006733549,0.0002196177,0.01125154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447595,"threshold_uncertainty_score":0.004842639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0332335720879361,"score_gpt":0.2265648340999642,"score_spread":0.1933312620120281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}