{"id":"W1968336312","doi":"10.1089/scd.2012.0218","title":"The Generation of Definitive Neural Stem Cells from <i>PiggyBac</i> Transposon-Induced Pluripotent Stem Cells Can Be Enhanced by Induction of the NOTCH Signaling Pathway","year":2012,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Mount Sinai Hospital; University of Regina; Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Neurotrauma Foundation","keywords":"Biology; Induced pluripotent stem cell; Noggin; Neurosphere; Neural stem cell; Embryonic stem cell; Cell biology; Notch signaling pathway; Leukemia inhibitory factor; Stem cell; Induced stem cells; Neural development; Bone morphogenetic protein; Adult stem cell; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005314596,0.0003314646,0.0003260693,0.00003965483,0.0003484187,0.00004483332,0.0003320652,0.0002326543,0.000006960265],"category_scores_gemma":[0.000001851847,0.0002260552,0.0001239413,0.0001438016,0.0001243128,0.00001781315,0.000172944,0.0002124948,0.000003478937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007255973,"about_ca_system_score_gemma":0.0002586291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001117196,"about_ca_topic_score_gemma":0.0001164981,"domain_scores_codex":[0.9973502,0.0003433979,0.0006979007,0.0004833733,0.0005806205,0.0005445388],"domain_scores_gemma":[0.9987504,0.00008331271,0.000381768,0.0004019154,0.00021158,0.0001710194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009211272,0.00009838094,0.0001620828,0.00006588353,0.000116323,4.646657e-7,0.001518258,0.000129458,0.9822522,0.00000487985,0.0001804118,0.01537952],"study_design_scores_gemma":[0.0006429342,0.0001325638,0.0001190229,0.00004901625,0.0000284475,0.000001329599,0.001636739,0.00005057563,0.9931943,0.000001290075,0.003874397,0.0002694028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958011,0.001583573,0.0006777945,0.00009953189,0.0007841837,0.0007391421,0.0002243045,0.000008417849,0.00008195544],"genre_scores_gemma":[0.9984136,0.0004443454,0.0002001668,0.00008485887,0.0001307524,0.0000600273,0.00006465857,0.00003756606,0.0005640242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01511012,"threshold_uncertainty_score":0.9218264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0332335720879361,"score_gpt":0.2265648340999642,"score_spread":0.1933312620120281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}