{"id":"W1968345969","doi":"10.1016/j.molcel.2012.04.021","title":"The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Université de Montréal; McGill University","keywords":"Biology; Repressor; Psychological repression; Transcription (linguistics); DNA; Transcription factor; Gene; Transcriptional regulation; Genetics; STAT3; Genome; Computational biology; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009239039,0.0004015557,0.0003564582,0.0009681835,0.0002942844,0.0004916209,0.0002938193,0.0005413668,0.005671121],"category_scores_gemma":[0.004487405,0.0001439331,0.0003570665,0.0004698815,0.0005689689,0.0004146551,0.0004840846,0.0006838646,0.001627937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000296714,"about_ca_system_score_gemma":0.0003425004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181831,"about_ca_topic_score_gemma":0.001227098,"domain_scores_codex":[0.9994113,0.0001772934,0.00004148103,0.0001335858,0.0001412053,0.0000951362],"domain_scores_gemma":[0.9947634,0.002858357,0.0007591338,0.0006723299,0.0003731132,0.0005736484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01044844,0.0002579522,0.3095853,0.0002558708,0.0002408096,0.0006819624,0.0001248126,0.008707655,0.6242819,0.003052117,0.001327673,0.04103557],"study_design_scores_gemma":[0.0003719587,0.002273427,0.4207646,0.0001053598,0.0004387968,0.003884608,0.0002635274,0.1497776,0.4040518,0.01412953,0.003776471,0.0001623584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865875,0.0004062573,0.007000326,0.0001055923,0.00003569341,0.00003111373,0.001736915,0.0003576481,0.003738916],"genre_scores_gemma":[0.997601,0.0000482101,0.001467919,0.00003449694,0.00001340821,0.00001484352,0.0005151352,0.00004160126,0.0002634712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005671121,"threshold_uncertainty_score":0.01897174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0697560385352603,"score_gpt":0.3361931221380237,"score_spread":0.2664370836027634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}