{"id":"W1968345969","doi":"10.1016/j.molcel.2012.04.021","title":"The Stat3/GR Interaction Code: Predictive Value of Direct/Indirect DNA Recruitment for Transcription Outcome","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Université de Montréal; McGill University","keywords":"Biology; Repressor; Psychological repression; Transcription (linguistics); DNA; Transcription factor; Gene; Transcriptional regulation; Genetics; STAT3; Genome; Computational biology; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003639345,0.0001400515,0.0002313466,0.00007517134,0.0001137382,0.00001494072,0.00006171382,0.0000606352,0.00004595259],"category_scores_gemma":[0.00008628066,0.000101002,0.0002636799,0.00009952689,0.0000372476,0.00009955021,0.00001238775,0.0001555314,0.00001159676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366921,"about_ca_system_score_gemma":0.00003538292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002680192,"about_ca_topic_score_gemma":0.000004866868,"domain_scores_codex":[0.9989204,0.00008050418,0.0003603064,0.0001674381,0.0002133476,0.000257967],"domain_scores_gemma":[0.9992255,0.0001391973,0.0001562317,0.0002458787,0.0001346064,0.00009860325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005555065,0.000440981,0.001025138,0.00011092,0.0001538102,0.000002246175,0.0009768107,0.0001219778,0.991724,0.0002862252,0.001047249,0.003555143],"study_design_scores_gemma":[0.0008467919,0.0006286378,0.001514379,0.000063437,0.0003591604,0.000008828051,0.0003477481,0.001180963,0.8566148,0.00003321862,0.138308,0.00009400272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9185962,0.001681231,0.05110007,0.0008305426,0.002277198,0.002986806,0.0002021684,0.0001097909,0.02221601],"genre_scores_gemma":[0.9976884,0.00005735179,0.0006551367,0.0001563556,0.0001246719,0.0002508512,0.00007574502,0.0000318839,0.0009596163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1372608,"threshold_uncertainty_score":0.4118742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0697560385352603,"score_gpt":0.3361931221380237,"score_spread":0.2664370836027634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}