{"id":"W1968347386","doi":"10.4161/auto.25413","title":"Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy","year":2013,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Montreal Neurological Institute and Hospital; University of Ottawa","funders":"Canada Research Chairs; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mitophagy; PINK1; Biology; Parkin; Cell biology; Mitochondrion; Autophagy; Genetics; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001466822,0.0003992477,0.000566897,0.000186172,0.0002411654,0.0001319806,0.0001807917,0.0002161638,0.002012228],"category_scores_gemma":[0.0001359154,0.0003538018,0.0002722355,0.0001382216,0.0002117746,0.0003591977,0.0001099563,0.0001972409,0.0005396499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009578511,"about_ca_system_score_gemma":0.0001842238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002741619,"about_ca_topic_score_gemma":0.00001091394,"domain_scores_codex":[0.9977496,0.00007148191,0.0005356315,0.0006471213,0.0003928951,0.0006033136],"domain_scores_gemma":[0.9983657,0.0002261894,0.0001789578,0.0005684614,0.0001943318,0.0004663309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001765337,0.001894275,0.01230747,0.001061669,0.002522005,0.00072069,0.003429884,0.000007156393,0.892325,0.001416917,0.02563644,0.05691319],"study_design_scores_gemma":[0.006483705,0.0009136478,0.389907,0.0001382181,0.0002997716,0.00007971334,0.0003226957,0.0001450561,0.558772,0.00377859,0.03849669,0.000662879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884951,0.005721176,0.0003238474,0.0007134803,0.0006066761,0.003047018,0.00007369988,0.0002242129,0.0007948009],"genre_scores_gemma":[0.987242,0.0004049607,0.0005032414,0.002533267,0.0008738041,0.0009508099,0.0001459125,0.00009063865,0.00725535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3775996,"threshold_uncertainty_score":0.9998914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02875612833121057,"score_gpt":0.3035916879474496,"score_spread":0.2748355596162391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}