{"id":"W1968349511","doi":"10.2174/187231210791292717","title":"Assessment of Competitive and Mechanism-Based Inhibition by Clarithromycin: Use of Domperidone as a CYP3A Probe-Drug Substrate and Various Enzymatic Sources Including a New Cell-Based Assay with Freshly Isolated Human Hepatocytes","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Heart And Stroke Foundation Of Quebec; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Clarithromycin; CYP3A4; CYP3A; Microsome; Non-competitive inhibition; Pharmacology; Potency; Cytochrome P450; Drug metabolism; Biology; Chemistry; Drug; Biochemistry; Enzyme; In vitro; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001159037,0.0005746078,0.0009735697,0.0003528076,0.0003636555,0.00009590254,0.0002309765,0.0002583408,0.0002065861],"category_scores_gemma":[0.00003490088,0.0005209227,0.0001236624,0.0003364535,0.0006525679,0.0002698604,0.0001164541,0.001130944,0.00000254343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002402239,"about_ca_system_score_gemma":0.0002630985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006194806,"about_ca_topic_score_gemma":0.0001510328,"domain_scores_codex":[0.9966113,0.0009372944,0.0008025588,0.0006389398,0.0004500999,0.0005598168],"domain_scores_gemma":[0.9975356,0.0007260513,0.0007877839,0.0003099351,0.0002042603,0.0004363656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003037378,0.0005258908,0.004792009,0.0002571162,0.0002610034,0.00002961644,0.001214533,0.00138411,0.987712,0.002956438,0.0003810928,0.0001824333],"study_design_scores_gemma":[0.007898707,0.0001149637,0.004014308,0.0000963026,0.001019227,0.00001625361,0.0001465475,0.01252949,0.9706141,0.0004532506,0.002506495,0.00059037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906713,0.0009975438,0.005045005,0.001425497,0.0003284453,0.001132635,0.0002522879,0.00007448256,0.00007276351],"genre_scores_gemma":[0.9881974,0.0001324401,0.007721397,0.003516415,0.0001054723,0.00007922201,0.00012732,0.00007425224,0.00004600705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01709794,"threshold_uncertainty_score":0.9997242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03341953012497444,"score_gpt":0.3333685567766163,"score_spread":0.2999490266516418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}