{"id":"W1968349511","doi":"10.2174/187231210791292717","title":"Assessment of Competitive and Mechanism-Based Inhibition by Clarithromycin: Use of Domperidone as a CYP3A Probe-Drug Substrate and Various Enzymatic Sources Including a New Cell-Based Assay with Freshly Isolated Human Hepatocytes","year":2010,"lang":"en","type":"article","venue":"Drug Metabolism Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Heart And Stroke Foundation Of Quebec; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Clarithromycin; CYP3A4; CYP3A; Microsome; Non-competitive inhibition; Pharmacology; Potency; Cytochrome P450; Drug metabolism; Biology; Chemistry; Drug; Biochemistry; Enzyme; In vitro; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008055673,0.0008869831,0.0006120662,0.000330341,0.0002509615,0.0004201668,0.0004213363,0.0005598192,0.001081341],"category_scores_gemma":[0.0006384784,0.0003239429,0.0004515691,0.0004955414,0.0002770387,0.0003582983,0.000295741,0.0006910313,0.0004612355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003650733,"about_ca_system_score_gemma":0.000464412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845143,"about_ca_topic_score_gemma":0.002717816,"domain_scores_codex":[0.9988658,0.0003885601,0.0001323945,0.0002014374,0.000346709,0.00006503946],"domain_scores_gemma":[0.9995155,0.0001559781,0.00006899152,0.000103244,0.0001155659,0.00004063658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383074,0.00008730602,0.0007605416,0.00007882133,0.00003690528,0.00005692245,0.00004170294,0.00009560649,0.9953846,0.00005051102,0.00003354068,0.00313523],"study_design_scores_gemma":[0.00001636139,0.0006731304,0.005097679,0.000003106521,0.00004279791,0.0001917215,0.00001664312,0.0009188064,0.9924412,0.00001582564,0.0005759919,0.00000683821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449494,0.009323825,0.03929938,0.0001646492,0.0001288548,0.0003047153,0.0008289891,0.0003317092,0.00466843],"genre_scores_gemma":[0.969175,0.002935959,0.02165967,0.0000725832,0.00004265819,0.0002683568,0.001590426,0.00003969285,0.004215743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845143,"threshold_uncertainty_score":0.004260302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03341953012497444,"score_gpt":0.3333685567766163,"score_spread":0.2999490266516418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}