{"id":"W1968368047","doi":"10.1186/1471-2334-14-302","title":"Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment","year":2014,"lang":"en","type":"article","venue":"BMC Infectious Diseases","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital","funders":"Drugs for Neglected Diseases initiative","keywords":"Nifurtimox; Benznidazole; Chagas disease; Medicine; Biomarker; Internal medicine; Trypanosoma cruzi; Disease; Parasitology; Medical microbiology; Immunology; Pathology; Biology; Parasite hosting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001115159,0.0001718844,0.0002514261,0.0002496668,0.00005136869,0.00001415156,0.00005875012,0.00004613605,0.0002689706],"category_scores_gemma":[0.0003749367,0.0001382901,0.0001729944,0.0003045325,0.0001421259,0.0001072654,0.00004107308,0.00005843861,0.00004713067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391771,"about_ca_system_score_gemma":0.0002408461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000842583,"about_ca_topic_score_gemma":0.0001437352,"domain_scores_codex":[0.9987838,0.00009219351,0.0002504478,0.0002910697,0.0002768374,0.0003056218],"domain_scores_gemma":[0.9987733,0.0001038956,0.00007088466,0.0004149995,0.0001492843,0.0004875857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001125229,0.00237104,0.9926199,0.0001418802,0.00008511797,0.000005583847,0.00005821419,0.00001402043,0.00006452632,0.00008228022,0.0004997648,0.002932465],"study_design_scores_gemma":[0.003738148,0.001136156,0.993027,0.00009291789,0.0001439866,0.00000114757,0.00002521696,0.0003289167,0.00008269061,0.0002299238,0.001082067,0.0001118007],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958395,0.0002888398,0.0001382161,0.0001327119,0.00007095824,0.0009550353,0.0006530388,0.00007628939,0.001845442],"genre_scores_gemma":[0.9988761,0.000107673,0.0000238857,0.00008092883,0.00009475162,0.0004786929,0.0001545924,0.00002241341,0.0001609668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003036626,"threshold_uncertainty_score":0.5639307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00850986176158894,"score_gpt":0.2651001647888112,"score_spread":0.2565903030272222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}