{"id":"W1968375364","doi":"10.1126/science.1259206","title":"Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies","year":2014,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Epitope; Virology; Antibody; Biology; AIDS Vaccines; Immunization; Glycoprotein; Antigen; Recombinant DNA; Immunology; Human immunodeficiency virus (HIV); Molecular biology; Genetics; Vaccine trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561108,0.0001608567,0.0001448976,0.0001082259,0.0001058213,0.0004398557,0.0002299231,0.0002330136,0.002104244],"category_scores_gemma":[0.0002142825,0.0001655007,0.0001011064,0.00007334229,0.0002177661,0.0002179902,0.000258337,0.0003589263,0.0003504725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003285564,"about_ca_system_score_gemma":0.0001357571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000337659,"about_ca_topic_score_gemma":0.0004131896,"domain_scores_codex":[0.9997867,0.00003286304,0.00001103858,0.00004313302,0.00003817098,0.00008814842],"domain_scores_gemma":[0.9998615,0.00004509578,0.00003055684,0.00001329861,0.00001701461,0.00003254537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007206495,0.00002513946,0.0003852682,0.00000551122,0.000001683918,0.00001804687,0.000008732371,0.00006275171,0.9983765,0.0002232718,0.0000154396,0.000805529],"study_design_scores_gemma":[0.00002648006,0.0002798686,0.01049446,0.000003855301,0.00001182471,0.0002229733,0.00003331921,0.002635028,0.9848188,0.0001942237,0.001273108,0.000005991721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980848,0.0001780249,0.0005223132,0.00001606162,0.00000463693,0.00000766359,0.00001425523,0.00001079972,0.001161518],"genre_scores_gemma":[0.9991722,0.00006911319,0.0002919729,0.00002113452,0.000002546387,0.000005707813,0.00002255924,0.000008504998,0.0004063387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002104244,"threshold_uncertainty_score":0.007039428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916617598481983,"score_gpt":0.2823456130383264,"score_spread":0.2631794370535065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}