{"id":"W1968375364","doi":"10.1126/science.1259206","title":"Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies","year":2014,"lang":"en","type":"article","venue":"Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Epitope; Virology; Antibody; Biology; AIDS Vaccines; Immunization; Glycoprotein; Antigen; Recombinant DNA; Immunology; Human immunodeficiency virus (HIV); Molecular biology; Genetics; Vaccine trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283409,0.00004266791,0.00007324167,0.00007776821,0.0002018884,0.00001269877,0.0001008344,0.0000247147,0.00002524988],"category_scores_gemma":[0.00004705017,0.00003361361,0.00001145828,0.0001184818,0.0009075413,0.0001104047,0.00003202551,0.00003546504,0.00008940633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000867233,"about_ca_system_score_gemma":0.00002487388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000378584,"about_ca_topic_score_gemma":0.000005692305,"domain_scores_codex":[0.9995327,0.00004337528,0.00007710716,0.0001519344,0.00003586476,0.0001590102],"domain_scores_gemma":[0.9997371,0.00003276576,0.00003558794,0.0001209156,0.00005738313,0.00001619392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008340047,0.00002275649,0.02154244,0.000007042744,0.000004330739,1.563821e-7,0.0002688582,0.000005419728,0.9689952,0.005050295,0.00005270389,0.004042499],"study_design_scores_gemma":[0.0002537681,0.00007927308,0.3961912,0.00001787576,0.000002296515,0.000008526515,0.00008642267,0.0000828796,0.600665,0.0004553431,0.002114489,0.0000429568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975413,0.0009089328,0.000106226,0.0002382585,0.00004944771,0.00006456525,0.000008883336,0.00001413035,0.001068227],"genre_scores_gemma":[0.9994488,0.00009965282,0.0001838474,0.000008491666,0.000003774812,0.000002109186,0.00002190556,0.000001504913,0.0002298782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3746488,"threshold_uncertainty_score":0.3343874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916617598481983,"score_gpt":0.2823456130383264,"score_spread":0.2631794370535065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}