{"id":"W1968400553","doi":"10.1002/jgm.797","title":"Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter","year":2005,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Heart, Lung, and Blood Institute","keywords":"Transduction (biophysics); Respiratory epithelium; Lung; Epithelium; Transgene; Gene delivery; Pathology; Aerosolization; Viral vector; Lysophosphatidylcholine; Immunology; Biology; Genetic enhancement; Medicine; Anatomy; Inhalation; Internal medicine; Gene; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001481134,0.0001458092,0.000246391,0.0001163387,0.00008250403,0.000007568918,0.0003942172,0.00008962505,0.00007333314],"category_scores_gemma":[0.00004492666,0.00009599879,0.00006280973,0.0001104107,0.000075623,0.00002209691,0.00004223988,0.0001834455,0.000001854245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006738114,"about_ca_system_score_gemma":0.0001525669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005241322,"about_ca_topic_score_gemma":0.0002892699,"domain_scores_codex":[0.9983659,0.0002489923,0.0005169659,0.0001440319,0.0004773046,0.0002467415],"domain_scores_gemma":[0.9987832,0.00002071976,0.0002713617,0.0003716417,0.0003473961,0.0002056913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00383113,0.000132937,0.00003853028,0.000008220867,0.0000700324,0.000002673478,0.001085825,0.009191494,0.9728067,3.893486e-7,0.00004089865,0.01279117],"study_design_scores_gemma":[0.001307855,0.009487485,0.0001554698,0.00003331789,0.00007379489,0.0001345298,0.0002996428,0.001435049,0.9869104,0.00000668628,0.00005604932,0.00009972152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889566,0.001923411,0.008279139,0.0005050797,0.0000946835,0.0002081778,0.00000481887,0.000002802573,0.00002527882],"genre_scores_gemma":[0.996372,0.0002792989,0.001185513,0.0005168953,0.001568778,0.00000155809,0.00001141081,0.00002633356,0.00003814283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0141037,"threshold_uncertainty_score":0.3914717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0286800005063767,"score_gpt":0.3340180710833929,"score_spread":0.3053380705770162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}