{"id":"W1968403663","doi":"10.1002/cbic.201100203","title":"Tight Binding of Transition‐State Analogues to a Peptidyl‐Aminoacyl‐<scp>L</scp>/<scp>D</scp>‐Isomerase from Frog Skin","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität Wien; Medizinische Universität Wien; Austrian Science Fund","keywords":"Peptide; Dermorphin; Stereochemistry; Chemistry; Amino acid; Isomerase; Residue (chemistry); Biochemistry; Peptide sequence; Nonribosomal peptide; Transition state analog; Active site; Enzyme; Biosynthesis; Opioid peptide; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001926214,0.0004864358,0.0007469702,0.0002734718,0.0002324603,0.0000350789,0.0004903809,0.0004209653,0.0003678431],"category_scores_gemma":[0.0002017639,0.0004767526,0.0003485161,0.0003346882,0.0004487004,0.0002344746,0.0001657675,0.0004197427,0.001089349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000560216,"about_ca_system_score_gemma":0.00007940424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008904202,"about_ca_topic_score_gemma":0.00006945688,"domain_scores_codex":[0.9977452,0.0001026087,0.0005961119,0.0006916297,0.00008377551,0.0007807288],"domain_scores_gemma":[0.9984536,0.0004740206,0.0002960449,0.0005242305,0.000134548,0.0001176234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003788153,0.0003634081,0.0004924407,0.00006001867,0.0004220249,0.00001992934,0.01856135,0.000002463289,0.9410287,0.00007287454,0.03833443,0.000604459],"study_design_scores_gemma":[0.001132193,0.0002028426,0.002198789,0.0001744052,0.0001302987,0.00002394421,0.006385508,0.00000266907,0.9783248,0.0002638962,0.01100639,0.0001542967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888813,0.001231895,0.0004076021,0.00004996999,0.0004506871,0.0003240444,0.0009680618,0.0001422669,0.007544133],"genre_scores_gemma":[0.9855444,0.000177512,0.001005503,0.0003670089,0.0001192072,0.00003051119,0.0008463251,0.00006533744,0.01184416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03729605,"threshold_uncertainty_score":0.9997684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780303057363252,"score_gpt":0.2105874363167979,"score_spread":0.1927844057431654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}