{"id":"W1968442411","doi":"10.1126/scisignal.2000416","title":"Rapid Evolution of Functional Complexity in a Domain Family","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PDZ domain; Multicellular organism; Mutagenesis; Computational biology; Biology; Domain (mathematical analysis); Flexibility (engineering); Genetics; Mutation; Ligand (biochemistry); Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256223,0.0001754517,0.000184284,0.0004346958,0.0002969585,0.0003891093,0.0002386259,0.0002823798,0.0007145603],"category_scores_gemma":[0.0007047122,0.0001540561,0.0002049647,0.0002765937,0.0003161176,0.0004714107,0.0003331038,0.0004874941,0.000146957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004154821,"about_ca_system_score_gemma":0.0001624268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000231861,"about_ca_topic_score_gemma":0.0003100948,"domain_scores_codex":[0.9998705,0.00002186167,0.00000715217,0.00003876306,0.00003700688,0.00002470617],"domain_scores_gemma":[0.9996625,0.0001230866,0.00006750417,0.000055087,0.00003562227,0.00005617821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001909117,0.00005574136,0.01044589,0.000035835,0.0000476637,0.0002772852,0.0001075907,0.007458709,0.9615074,0.003495115,0.00008067337,0.01629704],"study_design_scores_gemma":[0.0001399058,0.001086976,0.2271846,0.00004296134,0.0002499112,0.007007995,0.0004253048,0.1633813,0.5566599,0.02445109,0.01924502,0.0001249736],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956133,0.00007736943,0.003808602,0.0000354836,0.000001436998,0.000003642756,0.00003732655,0.00002923791,0.0003935143],"genre_scores_gemma":[0.9947801,0.00009209067,0.004700722,0.00002618896,0.000002564686,0.000007557554,0.0001256922,0.00001550319,0.0002496399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007145603,"threshold_uncertainty_score":0.003014624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528183054347596,"score_gpt":0.2445467213044873,"score_spread":0.2192648907610113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}