{"id":"W1968442411","doi":"10.1126/scisignal.2000416","title":"Rapid Evolution of Functional Complexity in a Domain Family","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"PDZ domain; Multicellular organism; Mutagenesis; Computational biology; Biology; Domain (mathematical analysis); Flexibility (engineering); Genetics; Mutation; Ligand (biochemistry); Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000655678,0.00005461636,0.00006891632,0.0000709847,0.00007288393,0.00001248402,0.0001443912,0.0000418697,0.000008659657],"category_scores_gemma":[0.00001684885,0.00005153524,0.00003085152,0.0002605132,0.0002369283,0.000007202814,0.00003311635,0.00005049224,0.000001897835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002958859,"about_ca_system_score_gemma":0.000147767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008994927,"about_ca_topic_score_gemma":0.00000541556,"domain_scores_codex":[0.9993442,0.00001240555,0.0001771007,0.0001429823,0.0001486521,0.0001746227],"domain_scores_gemma":[0.9997177,0.000003531068,0.00006196336,0.000122823,0.00005663622,0.00003735121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002270543,0.0000192745,0.0002546558,0.00000235274,0.000001330975,1.685646e-7,0.00005001753,0.001880106,0.9896423,0.004140879,0.00006147034,0.003924788],"study_design_scores_gemma":[0.003246645,0.001682139,0.3134181,0.0001759179,0.00001623155,0.00003578926,0.002913577,0.05029916,0.4285589,0.1949938,0.003626866,0.001032956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539498,0.0003939981,0.04276029,0.00005781113,0.00008845924,0.00006657548,0.000002706089,0.00000308994,0.002677271],"genre_scores_gemma":[0.9959348,0.000007043096,0.003840025,0.0001361996,0.0000606526,9.712346e-7,0.000007275897,0.000001551815,0.00001146218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5610834,"threshold_uncertainty_score":0.2101546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528183054347596,"score_gpt":0.2445467213044873,"score_spread":0.2192648907610113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}