{"id":"W1968461149","doi":"10.1515/bc.2001.102","title":"Cathepsins X and B Display Distinct Activity Profiles That Can Be Exploited for Inhibitor Design","year":2001,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Cathepsin B; Cathepsin A; Cathepsin O; Carboxypeptidase; Cathepsin; Chemistry; Dipeptide; Biochemistry; Cathepsin C; Endopeptidase; Enzyme; Cleavage (geology); Cathepsin L; Cathepsin H; Cathepsin L1; Stereochemistry; Biology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091763,0.0001566991,0.0002555414,0.00001492611,0.00009729782,0.00001783917,0.000043938,0.0001747291,0.0001610022],"category_scores_gemma":[0.0002718141,0.0001025383,0.000110631,0.00008975553,0.0001531155,0.00002407462,0.00003252993,0.0001174118,0.000002194868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004372511,"about_ca_system_score_gemma":0.0000290317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001446167,"about_ca_topic_score_gemma":0.000002694413,"domain_scores_codex":[0.9992327,0.00002301436,0.0001182508,0.0003157463,0.00009350727,0.000216777],"domain_scores_gemma":[0.9994366,0.0001307132,0.00005968821,0.000141949,0.00004148003,0.0001895481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003541615,0.0002358452,0.0304652,0.00006990672,0.00003371225,0.00003221239,0.00002269403,1.906987e-7,0.9670008,0.0000052842,0.0007922638,0.0009876998],"study_design_scores_gemma":[0.001198187,0.0001807512,0.02609015,0.0001360851,0.00006793482,0.00009477169,0.0001422487,0.0003057836,0.96868,0.00006583523,0.002797309,0.0002409869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958441,0.0000336437,0.001694287,0.001651965,0.000006618017,0.0002227573,0.0001171628,0.00008545605,0.0003440638],"genre_scores_gemma":[0.9975868,0.00003438674,0.0005402912,0.0002761827,0.0001995373,0.0001002904,0.0002885101,0.000008959969,0.000965049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004375056,"threshold_uncertainty_score":0.418139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102573689664775,"score_gpt":0.3016342815967634,"score_spread":0.1990605919319884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}