{"id":"W1968461149","doi":"10.1515/bc.2001.102","title":"Cathepsins X and B Display Distinct Activity Profiles That Can Be Exploited for Inhibitor Design","year":2001,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Cathepsin B; Cathepsin A; Cathepsin O; Carboxypeptidase; Cathepsin; Chemistry; Dipeptide; Biochemistry; Cathepsin C; Endopeptidase; Enzyme; Cleavage (geology); Cathepsin L; Cathepsin H; Cathepsin L1; Stereochemistry; Biology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004798501,0.0006195537,0.0008308685,0.0003495557,0.0001700022,0.0007781301,0.0003891735,0.0006356966,0.0006387931],"category_scores_gemma":[0.0003932543,0.0003596982,0.0003988215,0.0003175842,0.0003410428,0.0003663014,0.0002425982,0.0007663585,0.0004531805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004215176,"about_ca_system_score_gemma":0.0004398086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003346143,"about_ca_topic_score_gemma":0.0006329595,"domain_scores_codex":[0.9997082,0.00005062941,0.00004205259,0.00006311649,0.00007278311,0.00006308232],"domain_scores_gemma":[0.9998173,0.00004252478,0.00004988586,0.00001923132,0.00002453957,0.00004648295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003804757,0.00008197889,0.0002913608,0.0001369422,0.00002650871,0.00009196885,0.00001755536,0.0005346462,0.9890156,0.0003246084,0.00006316781,0.009035093],"study_design_scores_gemma":[0.00024931,0.001467463,0.00130435,0.00001150131,0.00005966295,0.0006838405,0.00001723119,0.001526087,0.9886313,0.0001215817,0.005905793,0.00002190843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9250203,0.01717727,0.04913305,0.0003103436,0.00008360815,0.0007469277,0.0007496098,0.0002883712,0.006490532],"genre_scores_gemma":[0.9321104,0.01175237,0.05010552,0.0001745764,0.00002821161,0.0006241761,0.00105405,0.00004663955,0.004103944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008308685,"threshold_uncertainty_score":0.003058374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102573689664775,"score_gpt":0.3016342815967634,"score_spread":0.1990605919319884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}