{"id":"W1968471269","doi":"10.1074/jbc.m000381200","title":"NADPH Oxidase Activation Increases the Sensitivity of Intracellular Ca2+ Stores to Inositol 1,4,5-Trisphosphate in Human Endothelial Cells","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"NADPH oxidase; Superoxide; Intracellular; Inositol; Reactive oxygen species; Cell biology; Apocynin; Signal transduction; Biochemistry; Inositol phosphate; Second messenger system; NOX1; Extracellular; Chemistry; Biology; Receptor; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000259424,0.0002969996,0.0002852483,0.0002144939,0.0001296662,0.0003757625,0.0002504257,0.0003101172,0.001854205],"category_scores_gemma":[0.0003008916,0.000163327,0.0002460193,0.0002496049,0.0001314754,0.0001627827,0.0002202178,0.000656062,0.0003251539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315447,"about_ca_system_score_gemma":0.0001547085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408013,"about_ca_topic_score_gemma":0.001366067,"domain_scores_codex":[0.9997556,0.00005776067,0.00002531787,0.00004404501,0.0000619655,0.00005533551],"domain_scores_gemma":[0.9998593,0.00003731617,0.00003265884,0.00001815471,0.00002429815,0.00002824043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001387151,0.00003955312,0.0001224339,0.00002339595,0.000008223871,0.00006672453,0.00001317626,0.00001832248,0.9985372,0.00003413329,0.00007494589,0.0009232623],"study_design_scores_gemma":[0.00005687649,0.00059342,0.01102836,0.0000114979,0.00003679574,0.000403317,0.00003179192,0.0007721449,0.9842376,0.00005574104,0.002764323,0.000008097494],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878452,0.00568951,0.003286101,0.0003459106,0.0001064853,0.00003106398,0.0003713253,0.000174778,0.002149617],"genre_scores_gemma":[0.993947,0.001812072,0.001797612,0.0001323154,0.00003339958,0.00003293361,0.0004472884,0.00001419725,0.001783135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001854205,"threshold_uncertainty_score":0.006202936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01349335888237118,"score_gpt":0.2337082127340617,"score_spread":0.2202148538516905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}