{"id":"W1968482893","doi":"10.1002/em.21700","title":"Proliferating primary hepatocytes from the pUR288 <i>lacZ</i> plasmid mouse are valuable tools for genotoxicity assessment in vitro","year":2012,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; In vitro; Plasmid; lac operon; Biology; Ames test; Molecular biology; Genetics; Chemistry; Gene; Toxicity; Salmonella; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003367535,0.0002830613,0.0002516684,0.00002285844,0.0002200956,0.00008114907,0.0001731854,0.0001438087,0.00002185468],"category_scores_gemma":[0.00002022373,0.000238255,0.0001499093,0.00003423662,0.00009196872,0.00002369497,0.0002954623,0.0001175194,0.000004691636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001010217,"about_ca_system_score_gemma":0.00003900951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004473529,"about_ca_topic_score_gemma":0.00001670187,"domain_scores_codex":[0.9984134,0.0001317421,0.0002806332,0.0004651422,0.0002380751,0.0004710255],"domain_scores_gemma":[0.999311,0.00005837353,0.0001188569,0.0003671604,0.000007249374,0.0001373848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137556,0.0002403031,0.03003089,0.00001852486,0.0000798842,0.000004438296,0.0001030382,0.00008150997,0.9670148,0.000006575657,0.0001316092,0.002174635],"study_design_scores_gemma":[0.0008380357,0.00009648407,0.0710964,0.000007089691,0.00005724129,0.000009064107,0.0004264315,0.000154899,0.9214413,0.00001368938,0.005553092,0.0003063476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924546,0.002908971,0.002704602,0.0002210298,0.0000713133,0.001031428,0.0005356814,0.000009884766,0.0000624329],"genre_scores_gemma":[0.9914081,0.0002975613,0.004489732,0.002187554,0.0001917943,0.0004565595,0.0008461567,0.00004533904,0.0000772562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04557361,"threshold_uncertainty_score":0.9715756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129182091780562,"score_gpt":0.2277304195705205,"score_spread":0.2164385986527149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}