{"id":"W1968482893","doi":"10.1002/em.21700","title":"Proliferating primary hepatocytes from the pUR288 <i>lacZ</i> plasmid mouse are valuable tools for genotoxicity assessment in vitro","year":2012,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; In vitro; Plasmid; lac operon; Biology; Ames test; Molecular biology; Genetics; Chemistry; Gene; Toxicity; Salmonella; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009505688,0.0009943547,0.0005325025,0.00151741,0.0005245556,0.0007674021,0.0007524994,0.0007823048,0.007727311],"category_scores_gemma":[0.0004143578,0.0006071042,0.0006752792,0.0006933153,0.0004263326,0.0005736666,0.0005976981,0.001790901,0.005123318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341693,"about_ca_system_score_gemma":0.0002803227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00059437,"about_ca_topic_score_gemma":0.001629674,"domain_scores_codex":[0.9991826,0.0001153368,0.0001193217,0.0002187631,0.000256449,0.0001074806],"domain_scores_gemma":[0.9990672,0.0002203349,0.0002245478,0.0002304953,0.0001237428,0.0001337445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009561388,0.00006489988,0.0001801043,0.00005028695,0.000005691423,0.00008791026,0.00002821275,0.00004224872,0.9973003,0.0002132868,0.0001683202,0.001763088],"study_design_scores_gemma":[0.00003017765,0.0004765507,0.003213231,0.00002004323,0.00003565056,0.0004599121,0.00003037903,0.0005649519,0.9857933,0.0001408008,0.009222297,0.00001265366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7212495,0.006680793,0.2165977,0.0008195351,0.0006088169,0.001872065,0.02351905,0.004797224,0.02385534],"genre_scores_gemma":[0.7104788,0.005474571,0.1808379,0.0006019771,0.0001919303,0.00303676,0.04041775,0.001503396,0.05745692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007727311,"threshold_uncertainty_score":0.02585047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129182091780562,"score_gpt":0.2277304195705205,"score_spread":0.2164385986527149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}