{"id":"W1968505518","doi":"10.1042/bj20130594","title":"The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+ release and destabilizes the N-terminal domains","year":2013,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor 2; Ryanodine receptor; HEK 293 cells; Mutation; Endoplasmic reticulum; Cytosol; Mutant; Cell biology; Biology; Chemistry; Genetics; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123925,0.0003121566,0.0003001567,0.0001992821,0.0001511948,0.0002649389,0.0003024447,0.0004546565,0.0012123],"category_scores_gemma":[0.0001448377,0.0001155598,0.0003071765,0.0001549558,0.0002469763,0.0001175405,0.0002438075,0.0005738863,0.0004483511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246328,"about_ca_system_score_gemma":0.0001473713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008371933,"about_ca_topic_score_gemma":0.0007231819,"domain_scores_codex":[0.9998302,0.00002312968,0.00002183275,0.00003364781,0.00006117809,0.00002998189],"domain_scores_gemma":[0.9999,0.00001945428,0.00002811876,0.00001035108,0.000008227426,0.00003385133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000397148,0.00001473793,0.00004095325,0.000009140469,0.000003075172,0.0001046162,0.000004909362,0.00003033188,0.999401,0.00004200455,0.00003206522,0.0002775036],"study_design_scores_gemma":[0.00004642237,0.000273883,0.004130438,0.000006832167,0.00002281139,0.001390632,0.00002373231,0.002156795,0.9893539,0.00007177774,0.002511,0.00001177679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964095,0.0004402313,0.001551198,0.0001188159,0.00003366836,0.00002599061,0.0004146328,0.0001242234,0.0008818912],"genre_scores_gemma":[0.9962961,0.0003620996,0.001315057,0.00009621748,0.00001065244,0.00003026765,0.0004937927,0.00005496782,0.001340729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0012123,"threshold_uncertainty_score":0.00405556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006792234816038695,"score_gpt":0.246643734348122,"score_spread":0.2398514995320833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}