{"id":"W1968505603","doi":"10.1007/s10165-011-0557-x","title":"A multicenter, open-label, efficacy, pharmacokinetic, and safety study of adalimumab in Japanese patients with ankylosing spondylitis","year":2011,"lang":"en","type":"article","venue":"Modern Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Abbott (Canada)","funders":"","keywords":"Adalimumab; Medicine; Ankylosing spondylitis; Adverse effect; Pharmacokinetics; Clinical endpoint; Internal medicine; Open label; Clinical trial; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003064965,0.001142285,0.002198152,0.0003605282,0.0008525781,0.0006585926,0.000426278,0.0008238868,0.0007796082],"category_scores_gemma":[0.001833137,0.0007838703,0.001113366,0.0003910633,0.001201875,0.0009252518,0.0003340435,0.00147381,0.0002925165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005606327,"about_ca_system_score_gemma":0.001381615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001103472,"about_ca_topic_score_gemma":0.002170149,"domain_scores_codex":[0.9990127,0.0005359272,0.0000931015,0.0001329326,0.0001270679,0.00009821961],"domain_scores_gemma":[0.9983335,0.0002772595,0.0003504994,0.0001372393,0.0001823247,0.0007191737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6270755,0.09647345,0.08425429,0.001536253,0.003215158,0.0007864335,0.002449017,0.001247688,0.07769278,0.0002331111,0.001540707,0.1034956],"study_design_scores_gemma":[0.2701656,0.618132,0.1031881,0.0000368964,0.001589037,0.0005259616,0.0002823098,0.001254762,0.002693496,0.0001133951,0.001943301,0.00007518773],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998489,0.0007349161,0.0001558115,0.00008689478,0.00002469275,0.0002527356,0.00005282366,0.000007221036,0.0001959026],"genre_scores_gemma":[0.9973823,0.0005674147,0.0007813181,0.0003373357,0.0001323712,0.0003478297,0.0001738629,0.000005767257,0.000271821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003064965,"threshold_uncertainty_score":0.01620924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03434346876204933,"score_gpt":0.2916874437938575,"score_spread":0.2573439750318082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}