{"id":"W1968516145","doi":"10.4236/ojmc.2015.51002","title":"Novel Cytocidal Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl) Benzenesulfonates and Benzenesulfonamides with Affinity to the Colchicine-Binding Site: Is the Phenyl 2-Imidazolidinone Moiety a New Haptophore for the Design of New Antimitotics?","year":2015,"lang":"en","type":"article","venue":"Open Journal of Medicinal Chemistry","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Stereochemistry; Podophyllotoxin; Colchicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021849,0.0003364423,0.0005958232,0.00001341879,0.0004376346,0.0002426415,0.001610323,0.000134489,0.00006413651],"category_scores_gemma":[0.0008853331,0.00009451119,0.0001336247,0.0004203806,0.0001815716,0.0002104667,0.0002431773,0.0004481745,0.000001995807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000672963,"about_ca_system_score_gemma":0.0004181261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005219572,"about_ca_topic_score_gemma":0.0002434015,"domain_scores_codex":[0.9977714,0.0000698716,0.0006461705,0.0003150418,0.0007944955,0.0004030238],"domain_scores_gemma":[0.995986,0.002097172,0.000733344,0.000199173,0.0005099992,0.0004742934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002902017,0.00007728057,0.001083768,0.00002613136,0.0001915247,0.00001770658,0.001080985,0.001702412,0.9784853,0.0000278495,0.01037313,0.004031866],"study_design_scores_gemma":[0.01434994,0.003553506,0.02105722,0.001798728,0.002002173,0.004141994,0.01899217,0.006504098,0.9039129,0.0006558617,0.02173594,0.001295502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714709,0.00167854,0.002086798,0.02310719,0.0001739482,0.001151546,0.0001982907,0.000009011507,0.0001237654],"genre_scores_gemma":[0.9953442,0.0001251715,0.002212565,0.0007261308,0.001344876,0.00001406355,0.00001670516,0.000006410133,0.0002098443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07457246,"threshold_uncertainty_score":0.3854055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07904646562108715,"score_gpt":0.2592605358586891,"score_spread":0.1802140702376019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}