{"id":"W1968516145","doi":"10.4236/ojmc.2015.51002","title":"Novel Cytocidal Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl) Benzenesulfonates and Benzenesulfonamides with Affinity to the Colchicine-Binding Site: Is the Phenyl 2-Imidazolidinone Moiety a New Haptophore for the Design of New Antimitotics?","year":2015,"lang":"en","type":"article","venue":"Open Journal of Medicinal Chemistry","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Moiety; Chemistry; Stereochemistry; Podophyllotoxin; Colchicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007884735,0.0002521802,0.0002064843,0.00007224655,0.00006902955,0.0001326097,0.0002268138,0.0001556203,0.0005681271],"category_scores_gemma":[0.00007190633,0.00009675584,0.0001042688,0.0000643093,0.000234798,0.0001261509,0.0001098899,0.0001993775,0.0002081171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557196,"about_ca_system_score_gemma":0.0001984139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007487425,"about_ca_topic_score_gemma":0.001468481,"domain_scores_codex":[0.9999567,0.000008681706,0.000002266107,0.000007053991,0.00001191383,0.00001334531],"domain_scores_gemma":[0.999956,0.000006137277,0.00001542928,0.000003387352,0.000006148003,0.00001285875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002257152,0.00002753931,0.0003043341,0.00005553589,0.000004373017,0.00006659765,0.00002396582,0.0002844841,0.994046,0.0003454943,0.00006972867,0.004546148],"study_design_scores_gemma":[0.0001711131,0.0014186,0.004144977,0.00000703163,0.00001905538,0.0003489096,0.0000481703,0.002728172,0.9847682,0.00009950628,0.006234521,0.00001173494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894964,0.003621852,0.004203484,0.0001094861,0.00002496671,0.00005351796,0.0001057644,0.00009039915,0.002294133],"genre_scores_gemma":[0.9915486,0.002056625,0.004236097,0.00008415442,0.00001173412,0.00005263498,0.000142979,0.00001054238,0.001856684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007487425,"threshold_uncertainty_score":0.001900554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07904646562108715,"score_gpt":0.2592605358586891,"score_spread":0.1802140702376019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}