{"id":"W1968538911","doi":"10.1200/jco.2011.38.5732","title":"Design Issues in Randomized Phase II/III Trials","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Randomized controlled trial; Medicine; Phase (matter); Selection (genetic algorithm); N of 1 trial; Clinical trial; Accrual; Internal medicine; Computer science; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.6343317,0.003267883,0.006137062,0.003256073,0.002306538,0.008291336,0.005596865,0.009082642,0.006733247],"category_scores_gemma":[0.7296525,0.003225964,0.00408543,0.005468204,0.01393919,0.00818808,0.004848554,0.01446858,0.0031068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005769142,"about_ca_system_score_gemma":0.01043207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009319089,"about_ca_topic_score_gemma":0.000977552,"domain_scores_codex":[0.173418,0.7786292,0.02186958,0.006529153,0.01846905,0.001085021],"domain_scores_gemma":[0.2327612,0.6779529,0.02612016,0.04173208,0.01939338,0.002040266],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.008120911,0.0004893355,0.00247936,0.008151191,0.00195885,0.0003731576,0.002335284,0.0147893,0.000748412,0.618382,0.03524022,0.306932],"study_design_scores_gemma":[0.008539515,0.003569413,0.001316135,0.004982936,0.0008408176,0.0006083864,0.0004524821,0.03419906,0.001986975,0.8434113,0.09987868,0.0002142524],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.001873618,0.005528837,0.9473934,0.01420715,0.003596096,0.02045035,0.0002902132,0.0005495652,0.006110714],"genre_scores_gemma":[0.03792949,0.002091772,0.8705491,0.01099755,0.001768137,0.07458126,0.0001473971,0.0002553791,0.001679888],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3656683,"threshold_uncertainty_score":0.4509342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8981866011790793,"score_gpt":0.7525624720174812,"score_spread":0.1456241291615982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}