{"id":"W1968569455","doi":"10.1038/nature09000","title":"Deciphering the splicing code","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":933,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"RNA splicing; Exon; Intron; Alternative splicing; Biology; Computational biology; Genetics; Exonic splicing enhancer; Nonsense-mediated decay; RNA; Splicing factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000941515,0.0003219637,0.0004304647,0.0005492821,0.0005421085,0.001771636,0.0007036116,0.001116261,0.001952289],"category_scores_gemma":[0.001406472,0.0003105311,0.0002785449,0.0003926696,0.001601271,0.003071518,0.0007773127,0.002056336,0.001074687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000685091,"about_ca_system_score_gemma":0.0007689789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003943465,"about_ca_topic_score_gemma":0.0007177134,"domain_scores_codex":[0.9997641,0.00003651734,0.00001625955,0.00007073868,0.0000814518,0.0000310196],"domain_scores_gemma":[0.9993244,0.0002787015,0.00007494393,0.0001830761,0.00008618198,0.00005275478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002466544,0.00004054779,0.002437944,0.0002965379,0.00003164458,0.0005337323,0.0003708134,0.003422542,0.6195137,0.2363564,0.004811764,0.1319377],"study_design_scores_gemma":[0.00003242316,0.0001251876,0.003294041,0.0001024542,0.00005605249,0.001033648,0.0003891983,0.01679931,0.3482786,0.4995198,0.1303117,0.0000577266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6466815,0.04598444,0.2240698,0.02974719,0.004319106,0.00004769903,0.0009833016,0.001820816,0.04634616],"genre_scores_gemma":[0.8976594,0.02073951,0.06388029,0.003775079,0.001178874,0.00003424849,0.0007968486,0.0004223318,0.01151349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952289,"threshold_uncertainty_score":0.00653106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005504525637230791,"score_gpt":0.2837596198318373,"score_spread":0.2782550941946065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}