{"id":"W1968584844","doi":"10.4161/isl.1.3.9780","title":"Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cells","year":2009,"lang":"en","type":"article","venue":"Islets","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Calpastatin; Internal medicine; Endocrinology; Insulin; Calpain; Insulin oscillation; Pancreatic islets; Islet; Biology; Exocytosis; Secretion; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665394,0.0001118249,0.0001154817,0.00008405152,0.00002763473,0.00001607892,0.00005614272,0.0001429478,0.00003355303],"category_scores_gemma":[0.00002920621,0.0001133605,0.00005435973,0.0001442871,0.00002051523,0.000006420511,0.000008974542,0.00008972362,0.000006009374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003482168,"about_ca_system_score_gemma":0.00003805274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006706868,"about_ca_topic_score_gemma":0.00009649635,"domain_scores_codex":[0.9991466,0.0001037499,0.0002303281,0.0002457002,0.00009364635,0.0001799132],"domain_scores_gemma":[0.999739,0.000009494123,0.00005133041,0.0001392921,0.0000177468,0.00004316742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203409,0.0001045527,0.0006000088,0.00001151966,0.000003627553,0.000004058922,0.0001310358,0.0006779684,0.9899949,0.00001119217,0.0002518257,0.008005931],"study_design_scores_gemma":[0.005149094,0.0006546646,0.1987501,0.0002192748,0.00001956731,0.00001567913,0.0001327447,0.009293096,0.7751161,0.0005597098,0.009535002,0.0005549247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965353,0.00030057,0.002272197,0.0002180824,0.0001169919,0.0002497387,0.000005208016,0.00001308628,0.000288804],"genre_scores_gemma":[0.9988214,0.00006299386,0.0003306571,0.0003451578,0.000117418,0.0000129358,0.0000851272,0.000009924373,0.0002143983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2148787,"threshold_uncertainty_score":0.4622708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007109021320093194,"score_gpt":0.2347214672807874,"score_spread":0.2276124459606942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}