{"id":"W1968640862","doi":"10.1073/pnas.1006529107","title":"Identification of <i>BERP</i> (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA <sub>A</sub> receptors","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Biology; Postsynaptic potential; Cell biology; GABAA receptor; Pentylenetetrazol; Inhibitory postsynaptic potential; Protein subunit; Gene expression; Gene; Receptor; Transcription factor; Intracellular; Neuroscience; Molecular biology; Genetics; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008518007,0.0002088074,0.0001773287,0.0001628331,0.00009941887,0.0001502065,0.0001255926,0.0001798979,0.0007093391],"category_scores_gemma":[0.0001224188,0.00007058392,0.0001346896,0.00007762533,0.0001845977,0.0001209528,0.00009864337,0.000261503,0.0002177472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221055,"about_ca_system_score_gemma":0.00008957028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001987743,"about_ca_topic_score_gemma":0.0002495357,"domain_scores_codex":[0.9999597,0.000006417877,0.00000333953,0.0000119707,0.000008334279,0.00001024005],"domain_scores_gemma":[0.9999177,0.00001943089,0.00002601524,0.000007301288,0.000007093368,0.00002232105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009009861,0.000008194982,0.0003359475,0.00001237967,0.000002449041,0.0001480381,0.00000401441,0.00003122249,0.9982439,0.00005074073,0.00002245308,0.001050436],"study_design_scores_gemma":[0.00002176724,0.0002972469,0.01595401,0.000004450355,0.00002235304,0.001967195,0.0000193226,0.0009906162,0.9785874,0.0000963503,0.00203447,0.000004704768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995113,0.001003291,0.002670873,0.0001474604,0.00001352814,0.00001218825,0.0002519705,0.00005507996,0.0007325957],"genre_scores_gemma":[0.9939644,0.0006120226,0.003520683,0.000065027,0.00001149939,0.00001199642,0.0005289873,0.00001665726,0.001268832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007093391,"threshold_uncertainty_score":0.002372921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173840713980556,"score_gpt":0.2813990303920549,"score_spread":0.2596606232522493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}