{"id":"W1968646181","doi":"10.1074/jbc.m112.381251","title":"The Human Transporter Associated with Antigen Processing","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Transporter associated with antigen processing; Endoplasmic reticulum; Transporter; ATP-binding cassette transporter; Cell biology; Transmembrane domain; Transmembrane protein; Biology; Transport protein; Biochemistry; Antigen processing; Antigen presentation; Plasma protein binding; Cytosol; MHC class I; Biophysics; Major histocompatibility complex; Amino acid; Gene; Receptor; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006348489,0.0003839056,0.0003511195,0.0001805034,0.0002391358,0.0007123526,0.0003566354,0.0007539368,0.008552203],"category_scores_gemma":[0.0001268057,0.0001190483,0.0004194391,0.0005869466,0.0002152441,0.000383523,0.0002100893,0.0002941882,0.004533947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006453807,"about_ca_system_score_gemma":0.0004902455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003594161,"about_ca_topic_score_gemma":0.00126507,"domain_scores_codex":[0.9999295,0.00001680463,0.000003246346,0.00001484324,0.00002111933,0.00001450607],"domain_scores_gemma":[0.9999776,0.000003014617,0.000004285898,0.00000277896,0.000007234567,0.000005076333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002437538,0.0002440716,0.01020326,0.002323758,0.0002180558,0.007464925,0.0005437435,0.06228661,0.463891,0.1360281,0.0699887,0.2443703],"study_design_scores_gemma":[0.000363421,0.0004574377,0.007638986,0.0001428529,0.0001424709,0.006474341,0.0002283432,0.1875237,0.1198334,0.02565718,0.6514376,0.0001002964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.603626,0.04760185,0.1505167,0.003949401,0.001264546,0.00032477,0.02373913,0.006984849,0.1619928],"genre_scores_gemma":[0.8894228,0.009820906,0.02849243,0.0004081192,0.00007486818,0.0001120799,0.01620053,0.0002846454,0.05518355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008552203,"threshold_uncertainty_score":0.02860993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733611051552784,"score_gpt":0.266173430888905,"score_spread":0.2388373203733772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}