{"id":"W1968700451","doi":"10.1158/0008-5472.sabcs-09-23","title":"First Results from FACT – An Open-Label, Randomized Phase III Study Investigating Loading Dose of Fulvestrant Combined with Anastrozole Versus Anastrozole at First Relapse in Hormone Receptor Positive Breast Cancer.","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Fulvestrant; Anastrozole; Medicine; Tolerability; Tamoxifen; Breast cancer; Internal medicine; Clinical endpoint; Oncology; Estrogen; Aromatase inhibitor; Cancer; Estrogen receptor; Endocrinology; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001794763,0.001850904,0.002634108,0.0005063253,0.000446878,0.0009421132,0.0009834006,0.001748061,0.005484058],"category_scores_gemma":[0.001465325,0.0007289724,0.0016855,0.0004439449,0.001103177,0.001170259,0.0002956162,0.00268887,0.0009767476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000893914,"about_ca_system_score_gemma":0.001260382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355971,"about_ca_topic_score_gemma":0.003063117,"domain_scores_codex":[0.9993804,0.000344476,0.00003338978,0.0000773113,0.00005008272,0.0001144279],"domain_scores_gemma":[0.998757,0.000288044,0.0003232915,0.00010772,0.00007404674,0.0004499769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534726,0.02180698,0.000642418,0.0002745698,0.0006119829,0.00005578107,0.00005515481,0.0005804154,0.01038306,0.0001003202,0.001183634,0.01083304],"study_design_scores_gemma":[0.6062042,0.3861985,0.003859258,0.00002567784,0.0004604381,0.00006479803,0.00002599168,0.0003957779,0.001266132,0.00008978145,0.00138658,0.00002287606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819989,0.002542878,0.0007939968,0.0006447944,0.0004329159,0.00707739,0.004068023,0.0001885196,0.00225263],"genre_scores_gemma":[0.9741707,0.002684649,0.002613756,0.001341893,0.0005754652,0.009041332,0.004743546,0.00006145633,0.004767301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005484058,"threshold_uncertainty_score":0.01834595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106490875859826,"score_gpt":0.365630971919384,"score_spread":0.3245660631607857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}