{"id":"W1968717741","doi":"10.1074/jbc.m111.304592","title":"Altered Glutathione Homeostasis in Heart Augments Cardiac Lipotoxicity Associated with Diet-induced Obesity in Mice","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Lipotoxicity; Homeostasis; Internal medicine; Endocrinology; Glutathione; Obesity; Chemistry; Medicine; Insulin resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006934506,0.0002326453,0.0005163734,0.00003948149,0.00003314957,0.000009329534,0.0003464279,0.0005352939,0.00003857131],"category_scores_gemma":[0.0005215286,0.000158277,0.0001611985,0.0002013576,0.000119121,0.000007404584,0.0001464627,0.0004782096,0.000001692293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173508,"about_ca_system_score_gemma":0.00008598848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002509955,"about_ca_topic_score_gemma":0.00002490356,"domain_scores_codex":[0.9983383,0.0002236848,0.0005623508,0.0003406303,0.0001530268,0.000382047],"domain_scores_gemma":[0.9991254,0.00006927922,0.0003565954,0.0001813968,0.0001345973,0.0001327089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009571115,0.0004628306,0.2057289,0.000006761863,0.00007785501,0.00004253004,0.00003155395,0.000001789678,0.7924439,3.302188e-7,0.00004717299,0.0001992536],"study_design_scores_gemma":[0.0009188991,0.001024935,0.3108917,0.00005188294,0.00001166679,0.00004881011,0.0000795189,0.00000200355,0.6865475,0.00005696849,0.0001707747,0.000195355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988855,0.0005259646,0.000008938315,0.00005048745,0.0001201109,0.0001130206,0.00002310983,0.000006966082,0.000265866],"genre_scores_gemma":[0.9989482,0.0001988808,0.0004868145,0.0001236054,0.0001652674,0.000008402274,0.00004748954,0.000009060165,0.0000123381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1058964,"threshold_uncertainty_score":0.6454347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03805170894768899,"score_gpt":0.2575465712430292,"score_spread":0.2194948622953402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}