{"id":"W1968721371","doi":"10.1371/journal.pone.0005404","title":"Inorganic Polyphosphate Modulates TRPM8 Channels","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Polyphosphate; TRPM8; Transient receptor potential channel; Biophysics; Ion channel; Phosphatidylinositol; Chemistry; Biochemistry; Phosphatidylinositol 4,5-bisphosphate; HEK 293 cells; Patch clamp; Lipid bilayer; Cell biology; Biology; Receptor; Signal transduction; Phosphate; TRPV1; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006596,0.0001958242,0.0001364505,0.00008753037,0.00008878318,0.0002303198,0.000117213,0.0002394984,0.0005630527],"category_scores_gemma":[0.0002197318,0.00008382848,0.0001289952,0.00005356289,0.0001834911,0.0003059159,0.0001995238,0.0003033219,0.0001393451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000160365,"about_ca_system_score_gemma":0.00005926961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001253201,"about_ca_topic_score_gemma":0.0001252719,"domain_scores_codex":[0.9998933,0.00002084382,0.000009788095,0.00002244799,0.00002888873,0.00002473333],"domain_scores_gemma":[0.9999216,0.0000255017,0.00002192917,0.00000618185,0.000009590574,0.00001523142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000701944,0.000004910245,0.00007991629,0.00001678011,0.000001119899,0.00004060518,0.000006709968,0.00001439828,0.9990824,0.00004058551,0.00001056173,0.0006318391],"study_design_scores_gemma":[0.00001920946,0.0001767694,0.003543337,0.00000382075,0.000007014305,0.0003452781,0.00001915502,0.0008026058,0.9939261,0.0001019704,0.001052632,0.000002176738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946935,0.001943678,0.002033682,0.0001613453,0.00002785532,0.00002043667,0.00007278011,0.00003429977,0.001012407],"genre_scores_gemma":[0.9972722,0.0009466645,0.001040227,0.00006071919,0.00001418367,0.00001497947,0.00004817334,0.000009481174,0.0005934525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005630527,"threshold_uncertainty_score":0.001883626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862948202696852,"score_gpt":0.2395346473763613,"score_spread":0.2009051653493928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}