{"id":"W1968721371","doi":"10.1371/journal.pone.0005404","title":"Inorganic Polyphosphate Modulates TRPM8 Channels","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Polyphosphate; TRPM8; Transient receptor potential channel; Biophysics; Ion channel; Phosphatidylinositol; Chemistry; Biochemistry; Phosphatidylinositol 4,5-bisphosphate; HEK 293 cells; Patch clamp; Lipid bilayer; Cell biology; Biology; Receptor; Signal transduction; Phosphate; TRPV1; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001400433,0.0002429046,0.000539192,0.0001413396,0.0001222482,0.00004151333,0.0001257802,0.0001360789,0.0007776078],"category_scores_gemma":[0.0001187983,0.0002277308,0.0001360912,0.0003494993,0.00004838012,0.0001707556,0.00002764874,0.0001660837,0.0003593249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005920011,"about_ca_system_score_gemma":0.00006951372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004843981,"about_ca_topic_score_gemma":0.000003391015,"domain_scores_codex":[0.9983085,0.00002130462,0.0004030856,0.0003624963,0.0004531627,0.0004514455],"domain_scores_gemma":[0.9990744,0.00004397935,0.0001138619,0.0003706977,0.0001313427,0.0002657411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009960156,0.01433556,0.1033843,0.000582515,0.00183238,0.0002515011,0.004930843,0.00005017399,0.808955,0.007908039,0.005320798,0.05145285],"study_design_scores_gemma":[0.00330799,0.001194913,0.2294969,0.0007988178,0.0006865549,0.00003818994,0.00008353929,0.004015547,0.7541783,0.00489464,0.0007074345,0.000597188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869432,0.004341287,0.00004530228,0.005456084,0.0001181389,0.0004629976,0.00000836916,0.0003427898,0.002281787],"genre_scores_gemma":[0.9879636,0.0002972519,0.0009768485,0.002094347,0.0006607439,0.00001054679,0.00006377364,0.00004014994,0.007892735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1261126,"threshold_uncertainty_score":0.9286591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862948202696852,"score_gpt":0.2395346473763613,"score_spread":0.2009051653493928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}