{"id":"W1968749102","doi":"10.1371/journal.pone.0015574","title":"Intranasal Immunization with an Archaeal Lipid Mucosal Vaccine Adjuvant and Delivery Formulation Protects against a Respiratory Pathogen Challenge","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"National Research Council Canada; Directorate for Biological Sciences; Government of Canada","keywords":"Adjuvant; Nasal administration; Immunology; Immune system; Immunization; Medicine; Chemokine; Splenocyte; Francisella tularensis; Antigen; Proinflammatory cytokine; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008051,0.000301568,0.0002948087,0.0002771441,0.0001179103,0.0002349738,0.0001898473,0.0004685397,0.0005506258],"category_scores_gemma":[0.0001627018,0.0001306189,0.0002185186,0.00009422986,0.0001845629,0.0001736853,0.0002040167,0.000496232,0.000171373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887523,"about_ca_system_score_gemma":0.0002293005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004242191,"about_ca_topic_score_gemma":0.0005808034,"domain_scores_codex":[0.9998703,0.00002286695,0.00001000285,0.00002450988,0.00003257236,0.00003971387],"domain_scores_gemma":[0.9999166,0.00001125382,0.00002605782,0.00001072268,0.000009796971,0.00002560702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004170352,0.0002215151,0.0003390912,0.00004336486,0.00001050191,0.00003302094,0.00001240364,0.0001061442,0.994746,0.00005144251,0.00003496672,0.003984483],"study_design_scores_gemma":[0.0001432921,0.01075873,0.005682182,0.00003297365,0.00006837599,0.0004104313,0.00005801125,0.001736058,0.9779366,0.00007431621,0.003088873,0.00001002699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969963,0.000788367,0.00163329,0.00007148583,0.00003651762,0.00003127431,0.00006710939,0.00003582425,0.0003398687],"genre_scores_gemma":[0.9949656,0.0005380738,0.003013523,0.00006583862,0.00001862816,0.00003695686,0.000245438,0.000007421899,0.001108491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005506258,"threshold_uncertainty_score":0.001842022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04553400044693981,"score_gpt":0.2645819762730949,"score_spread":0.2190479758261551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}