{"id":"W1968753483","doi":"10.1016/j.bpj.2012.11.773","title":"Exceptionally Conserved Asparagines in the Pore-Lining Helices of Calcium and Sodium Channels Stabilize the Open State through Interdomain H-Bonds","year":2013,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Asparagine; Chemistry; Biophysics; Sodium channel; Residue (chemistry); Sodium; Amino acid; Stereochemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005687545,0.0003384215,0.0005139866,0.0002068687,0.0006752595,0.0005708897,0.0006532942,0.0005266098,0.0008312414],"category_scores_gemma":[0.001176945,0.0002277947,0.0002982427,0.0002079017,0.0007809158,0.0008642746,0.0008560389,0.0009116529,0.0003153548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468146,"about_ca_system_score_gemma":0.0002469447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002681871,"about_ca_topic_score_gemma":0.0004407249,"domain_scores_codex":[0.9997651,0.00005540436,0.00002309809,0.00004990572,0.00005556734,0.00005098698],"domain_scores_gemma":[0.9994984,0.0001125815,0.0001454454,0.00007911675,0.00004563807,0.0001188006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003703073,0.0003986676,0.02598891,0.0003744953,0.0004736124,0.005099381,0.0005916469,0.01508349,0.8789261,0.02475983,0.001334684,0.04326611],"study_design_scores_gemma":[0.001003079,0.002578591,0.06863324,0.00008763239,0.0007078819,0.01096052,0.001441856,0.08037844,0.7630355,0.05987408,0.01099673,0.0003024949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882116,0.0003803275,0.01020683,0.00007593097,0.00005429586,0.0000159885,0.00004626356,0.0001321658,0.000876531],"genre_scores_gemma":[0.9985089,0.00007333138,0.00119183,0.00003182204,0.000007498949,0.000004727787,0.00005225595,0.00001423242,0.0001153843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008312414,"threshold_uncertainty_score":0.003007889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260423648424718,"score_gpt":0.3063432431182269,"score_spread":0.2803008782757551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}