{"id":"W1968779775","doi":"10.1021/ja0651714","title":"Combination of a Dinuclear Zn<sup>2+</sup>Complex and a Medium Effect Exerts a 10<sup>12</sup>-Fold Rate Enhancement of Cleavage of an RNA and DNA Model System","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Chemistry; DNA; RNA; Cleavage (geology); Stereochemistry; Crystallography; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004056871,0.000188616,0.0005387334,0.000015331,0.00004409484,0.00001112841,0.000282915,0.000113196,0.000004749099],"category_scores_gemma":[0.00005243369,0.0001377749,0.0002958451,0.00009522979,0.0005585331,0.00001307938,0.000182299,0.0001520348,9.091831e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004443811,"about_ca_system_score_gemma":0.0000492729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002551251,"about_ca_topic_score_gemma":2.070156e-7,"domain_scores_codex":[0.9986694,0.00008245752,0.0005552305,0.0002074839,0.0002966922,0.0001887271],"domain_scores_gemma":[0.9985444,0.0000457985,0.0009071384,0.0002598524,0.0001447682,0.00009805788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003451549,0.000178334,0.0003160371,0.0002712438,0.000141538,7.594973e-7,0.0002066367,0.0002266085,0.995618,0.000004555437,0.002267256,0.0004238933],"study_design_scores_gemma":[0.00123949,0.0005831351,0.0004225118,0.0001150881,0.0001302385,0.00003062678,0.0005023993,0.01546681,0.9812608,0.00003556452,0.00008456745,0.0001287713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991922,0.0001446912,0.0001714799,0.0001160466,0.00001055092,0.0001106383,0.00002264594,0.0000036465,0.0002280509],"genre_scores_gemma":[0.9985029,0.00009149482,0.001162207,0.00007080057,0.00008818239,0.000002642801,0.00001138237,0.00002100033,0.00004944664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0152402,"threshold_uncertainty_score":0.5618297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005114055241847104,"score_gpt":0.2174817907211025,"score_spread":0.2123677354792554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}