{"id":"W1968783454","doi":"10.3389/fnmol.2014.00067","title":"MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms","year":2014,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Nicastrin; microRNA; Biology; Untranslated region; Three prime untranslated region; Single-nucleotide polymorphism; Genetics; Alzheimer's disease; Cell biology; Amyloid precursor protein; Gene; Messenger RNA; Genotype; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017368,0.0002907399,0.0003752573,0.0004731525,0.0001842339,0.0003043572,0.0001603263,0.0002829646,0.00102898],"category_scores_gemma":[0.0009140196,0.0001629232,0.000333132,0.0005328346,0.0002097249,0.00008434479,0.0001655755,0.0002118009,0.0002470373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861013,"about_ca_system_score_gemma":0.0001323703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305168,"about_ca_topic_score_gemma":0.001604648,"domain_scores_codex":[0.999543,0.0001184551,0.00006025672,0.0001429882,0.0001003838,0.00003502353],"domain_scores_gemma":[0.9995959,0.0001194314,0.0002027078,0.00002831043,0.00003272474,0.00002087568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003202495,0.00008607087,0.3721404,0.0003086132,0.00119889,0.003189292,0.0006261254,0.001520051,0.5742635,0.0008407105,0.00083995,0.04178389],"study_design_scores_gemma":[0.00006854271,0.0002111888,0.9407357,0.00003739512,0.0005006513,0.003794872,0.0001044261,0.003242322,0.04721185,0.0005076645,0.003545819,0.00003959064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995327,0.001932056,0.001572701,0.00008397437,0.00002039046,0.00001389377,0.0003074899,0.00004774173,0.0006946672],"genre_scores_gemma":[0.998208,0.0003414761,0.0008457735,0.00004726433,0.00001051198,0.00001423716,0.0001481422,0.00001145514,0.0003730518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305168,"threshold_uncertainty_score":0.003442287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003283662897035922,"score_gpt":0.1963401032150189,"score_spread":0.1930564403179829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}