{"id":"W1968783454","doi":"10.3389/fnmol.2014.00067","title":"MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms","year":2014,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université Laval","funders":"Canadian Institutes of Health Research; Alzheimer Society","keywords":"Nicastrin; microRNA; Biology; Untranslated region; Three prime untranslated region; Single-nucleotide polymorphism; Genetics; Alzheimer's disease; Cell biology; Amyloid precursor protein; Gene; Messenger RNA; Genotype; Disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003259826,0.0002151083,0.000178727,0.0001103103,0.0001187521,0.0000577435,0.000231348,0.0001206891,0.00000196475],"category_scores_gemma":[0.0005379484,0.0002362729,0.00004473274,0.0003011143,0.000261026,0.00001841771,0.0001500185,0.0001232694,0.000001636545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002682273,"about_ca_system_score_gemma":0.00002907747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000751969,"about_ca_topic_score_gemma":0.000001513119,"domain_scores_codex":[0.9981344,0.0002172863,0.0002360076,0.0008473739,0.0001866636,0.0003782189],"domain_scores_gemma":[0.9992686,0.000003402016,0.0001735488,0.0004048657,0.00004176995,0.0001078199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002504267,0.00004596553,0.01039958,0.0000161651,0.000003235984,0.000005258406,0.00001163769,0.000608582,0.9762362,0.000003756154,0.01224107,0.0004035199],"study_design_scores_gemma":[0.0003406936,0.00008937066,0.02497141,0.00003137334,0.00001069595,0.00002206155,0.00001147443,0.002413203,0.9597171,0.00005768114,0.01203318,0.0003017385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360471,0.001874891,0.06075329,0.0002546416,0.0006958857,0.0002996945,0.00002059385,0.00002679683,0.00002712463],"genre_scores_gemma":[0.9918771,0.00006081784,0.007321177,0.0003196558,0.00005652261,0.00001620303,0.0001012936,0.00003382749,0.000213448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05582997,"threshold_uncertainty_score":0.963493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003283662897035922,"score_gpt":0.1963401032150189,"score_spread":0.1930564403179829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}