{"id":"W1968805055","doi":"10.1038/cgt.2008.96","title":"Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells","year":2008,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Institutes of Health; Prostate Cancer Foundation","keywords":"LNCaP; Fas ligand; Cancer research; Cytotoxic T cell; Prostate cancer; Transduction (biophysics); Biology; Cancer cell; Apoptosis; Immunology; Cancer; In vitro; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003114504,0.0003602155,0.0007600127,0.0002129225,0.0001483408,0.00001571162,0.0002294899,0.0001415338,0.002001042],"category_scores_gemma":[0.00001207296,0.0003004654,0.0002515288,0.0004835798,0.0003298062,0.0001267442,0.00002818026,0.0003054412,0.000007801892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005575016,"about_ca_system_score_gemma":0.000852076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009919147,"about_ca_topic_score_gemma":0.0000338606,"domain_scores_codex":[0.9975007,0.0001573646,0.0004652801,0.0005555443,0.0006921057,0.0006289907],"domain_scores_gemma":[0.9985533,0.0001443611,0.0001953335,0.0005157129,0.0003498208,0.0002414275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004030744,0.0001189283,0.006684507,0.0001328743,0.0003344306,0.00006101392,0.005552355,0.000363029,0.8436088,7.351968e-7,0.0001339918,0.1389786],"study_design_scores_gemma":[0.008072446,0.0007570587,0.006473167,0.000278522,0.00004635926,0.00002271073,0.00008011127,0.0002917578,0.9799591,0.00002010572,0.003711112,0.0002875594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628545,0.03425338,0.00008247334,0.0002593852,0.0004273946,0.001591348,0.00007096597,0.00009406333,0.0003664854],"genre_scores_gemma":[0.8808792,0.114686,0.0003720807,0.0003991016,0.000664725,0.0005531124,0.00001821099,0.00012145,0.002306137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.138691,"threshold_uncertainty_score":0.9999447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039707577976087,"score_gpt":0.3157771978177423,"score_spread":0.2853801220379814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}